Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 9/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.57 |
| ▸ | KIF11 | P52732 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29996129 | 0.84 | HDAC1 (0.63) | HDAC1HDAC2GAAMAPTHDAC3 | |
| SCHEMBL26416452 | 0.84 | HDAC1 (0.63) | HDAC1HDAC2GAAMAPTHDAC3 | |
| SCHEMBL1424488 | 0.83 | HDAC1 (0.77) | HDAC1HDAC2GAAMAPTHDAC3 | |
| SCHEMBL20198551 | 0.81 | PTGS1 (0.60) | PTGS1GAAMAPTMAPK1KMT2A | |
| SCHEMBL29416601 | 0.80 | KIF11 (0.77) | PTGS1KIF11MEN1KMT2A | |
| SCHEMBL14959294 | 0.80 | KIF11 (0.77) | PTGS1KIF11MEN1KMT2A | |
| SCHEMBL21750915 | 0.79 | CA12 (0.56) | KIF11GAAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL28477629 | 0.79 | PTGS1 (0.64) | PTGS1HDAC1KIF11HDAC2GAA | |
| SCHEMBL28440005 | 0.79 | HDAC1 (0.56) | HDAC1HDAC2GAAMAPTHDAC3 | |
| SCHEMBL14972697 | 0.79 | CYP1A2 (0.64) | PTGS1HDAC1GAAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110269758-A1 | NAPHTHYRIDINONES AS PROTEIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2011-11-03 | — | — | US | disclosed |
| WO-2010002779-A2 | NAPHTHYRIDININONES AS AURORA KINASE INHIBITORS | MERCK SERONO S.A. (CH) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269758-A1 | NAPHTHYRIDINONES AS PROTEIN KINASE INHIBITORS | AURKA, AURKC, AURKB | PTGS1 2887/4885HDAC1 788/4885KIF11 1085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.