Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6832268 | 0.82 | MEN1 (0.46) | TDP1MEN1KMT2ATTRALB | |
| SCHEMBL3032884 | 0.81 | TDP1 (0.46) | TDP1MEN1KMT2ATTRALB | |
| SCHEMBL6832334 | 0.78 | MEN1 (0.50) | TDP1MEN1KMT2ATTRALB | |
| SCHEMBL17540361 | 0.76 | MEN1 (0.43) | MEN1KMT2APIN1ALDH1A1MAPT | |
| Water SCHEMBL28314114 | 0.75 | MEN1 (0.43) | TDP1MEN1KMT2ATTRALB | |
| SCHEMBL16122061 | 0.75 | CYP1A2 (0.47) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL26928102 | 0.75 | HSPB1 (0.48) | TDP1MEN1KMT2AHSPB1MERTK | |
| SCHEMBL1361699 | 0.74 | TDP1 (0.44) | TDP1RAB9AALDH1A1MAPTATM | |
| SCHEMBL11649655 | 0.73 | HSPB1 (0.50) | TDP1MEN1KMT2ATTRALB | |
| SCHEMBL2410906 | 0.72 | TDP1 (0.47) | TDP1MEN1KMT2ATTRALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004113303-A1 | INDAZOLE/PYRZOLO[4,3-c]PYRIDIN DERIVATIVES AS JNK INHIBITORS, COMPOSITIONS AND METHODS RELATED THERETO AS WELL AS INTERMEDIATE THEREOF | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | WO | disclosed |