Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | ALB | P02768 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.39 |
| ▸ | HSPB1 | P04792 | 4/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.35 |
| ▸ | TLR4 | O00206 | 1/20 | 0.35 |
| ▸ | TLR2 | O60603 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6832334 | 0.95 | MEN1 (0.50) | MEN1TTRALBTHRBKMT2A | |
| SCHEMBL1361699 | 0.82 | TDP1 (0.44) | TDP1SMN1; SMN2MAPTLMNAALDH1A1 | |
| SCHEMBL6829291 | 0.82 | TDP1 (0.41) | MEN1TTRALBTHRBKMT2A | |
| SCHEMBL2410906 | 0.77 | TDP1 (0.47) | MEN1TTRALBTHRBKMT2A | |
| SCHEMBL15820028 | 0.76 | ALDH1A1 (0.45) | MEN1KMT2ATDP1MAPTLMNA | |
| SCHEMBL2127539 | 0.72 | SLC6A4 (0.44) | MEN1KMT2ATDP1SMN1; SMN2MAPT | |
| SCHEMBL18956840 | 0.72 | TDP1 (0.54) | MEN1TTRALBTHRBKMT2A | |
| SCHEMBL18956882 | 0.72 | TDP1 (0.54) | MEN1TTRALBTHRBKMT2A | |
| SCHEMBL938815 | 0.72 | MEN1 (0.69) | MEN1TTRALBTHRBKMT2A | |
| SCHEMBL22904575 | 0.71 | CYP1A2 (0.47) | MEN1KMT2ASMN1; SMN2EPAS1ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004113303-A1 | INDAZOLE/PYRZOLO[4,3-c]PYRIDIN DERIVATIVES AS JNK INHIBITORS, COMPOSITIONS AND METHODS RELATED THERETO AS WELL AS INTERMEDIATE THEREOF | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | WO | disclosed |