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SCHEMBL6829334

SCHEMBL6829334

CN1CC[C@@H](Oc2cc(NS(=O)(=O)c3cc(Cl)c(-c4ccc(F)cc4)s3)ccc2Cl)C1

nearest known ligand 0.56

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ UTS2R Q9UKP6 12/20 0.56
▸ HTR2C P28335 2/20 0.42
▸ HTR2B P41595 1/20 0.42
▸ GHSR Q92847 1/20 0.40
▸ HTR6 P50406 2/20 0.38
▸ SCD O00767 1/20 0.37
▸ DRD2 P14416 1/20 0.37
▸ DRD3 P35462 1/20 0.37
▸ SGK1 O00141 3/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6829339 1.00 UTS2R (0.56) UTS2RHTR2CHTR2BGHSRHTR6
SCHEMBL6828384 0.93 UTS2R (0.57) UTS2RHTR2CHTR2BHTR6DRD2
SCHEMBL6828386 0.93 UTS2R (0.57) UTS2RHTR2CHTR2BHTR6DRD2
SCHEMBL6828752 0.92 UTS2R (0.56) UTS2RHTR2CHTR2BHTR6DRD2
SCHEMBL8339325 0.90 UTS2R (0.54) UTS2RHTR2CHTR2BHTR6SCD
SCHEMBL6828911 0.89 UTS2R (0.58) UTS2RGHSR
SCHEMBL6828914 0.89 UTS2R (0.58) UTS2RGHSR
SCHEMBL6830599 0.89 UTS2R (0.53) UTS2RHTR2CHTR6DRD2DRD3
SCHEMBL6828486 0.87 UTS2R (0.53) UTS2RHTR6SCD
SCHEMBL6828484 0.87 UTS2R (0.53) UTS2RHTR6SCD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004043368-A2 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 — — WO claimed
WO-2004043368-A2 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 — — WO disclosed