SCHEMBL6829580

SCHEMBL6829580

COc1ncc(Cl)c(Nc2ncnc3cc(OCCN4CCOCC4)cc(OC(C)C)c23)n1

nearest known ligand 0.78

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SRC P12931 20/20 0.78
KDR P35968 18/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6829362 0.88 SRC (1.00) SRCKDR
SCHEMBL6826661 0.85 SRC (0.69) SRCKDR
SCHEMBL7132585 0.85 SRC (0.69) SRCKDR
SCHEMBL3675427 0.82 SRC (0.81) SRCKDR
SCHEMBL6831384 0.80 SRC (0.75) SRCKDR
SCHEMBL3281905 0.80 SRC (1.00) SRCKDR
SCHEMBL6826867 0.79 SRC (0.65) SRCKDR
SCHEMBL3672594 0.79 SRC (0.75) SRCKDR
SCHEMBL6829220 0.78 SRC (0.74) SRCKDR
SCHEMBL6829415 0.78 SRC (0.60) SRCKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004108710-A1 4-PYRIMIDINYL QUINAZOLINE DERIVATIVES FOR USE IN THE TREATMENT OF TUMOURS ASTRAZENECA AB (SE) 2004-12-16 WO disclosed