Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 11/20 | 1.00 |
| ▸ | ESR2 | Q92731 | 11/20 | 1.00 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | SLC22A8 | Q8TCC7 | 5/20 | 0.37 |
| ▸ | SLC22A6 | Q4U2R8 | 3/20 | 0.37 |
| ▸ | KCNJ1 | P48048 | 4/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13978611 | 0.85 | ESR2 (0.73) | ESR1ESR2PSMB5SLC22A8SLC22A6 | |
| SCHEMBL6923119 | 0.80 | ESR1 (0.67) | ESR1ESR2PSMB5SLC22A8SLC22A6 | |
| SCHEMBL29728674 | 0.78 | ESR1 (0.64) | ESR1ESR2PSMB5KCNJ1KCNH2 | |
| SCHEMBL1429217 | 0.78 | PSMB5 (0.68) | ESR1ESR2PSMB5 | |
| SCHEMBL286648 | 0.78 | ESR1 (0.64) | ESR1ESR2PSMB5KCNJ1KCNH2 | |
| SCHEMBL803200 | 0.77 | ESR1 (0.62) | ESR1ESR2KCNJ1KCNH2ACHE | |
| SCHEMBL803264 | 0.71 | ESR1 (0.56) | ESR1ESR2KCNJ1KCNH2 | |
| SCHEMBL783930 | 0.70 | ESR1 (0.54) | ESR1ESR2PSMB5 | |
| SCHEMBL6924719 | 0.69 | ESR1 (1.00) | ESR1ESR2PSMB5SLC22A8SLC22A6 | |
| SCHEMBL802785 | 0.68 | ESR1 (0.51) | ESR1ESR2KCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004073612-A2 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO. INC. (US) | 2004-09-02 | — | — | WO | claimed |