Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 15/20 | 1.00 |
| ▸ | ESR2 | Q92731 | 15/20 | 1.00 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.39 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6923119 | 0.78 | ESR1 (0.67) | ESR1ESR2SLC22A6SLC22A8PSMB5 | |
| SCHEMBL26908656 | 0.70 | ESR2 (0.54) | ESR1ESR2 | |
| SCHEMBL6923464 | 0.70 | ESR1 (0.54) | ESR1ESR2TYR | |
| SCHEMBL6830103 | 0.69 | ESR1 (1.00) | ESR1ESR2SLC22A6SLC22A8PSMB5 | |
| SCHEMBL1429217 | 0.69 | PSMB5 (0.68) | ESR1ESR2PSMB5KDM4EGAA | |
| SCHEMBL6828658 | 0.68 | ESR1 (1.00) | ESR1ESR2TYR | |
| SCHEMBL6825238 | 0.67 | ESR1 (1.00) | ESR1ESR2SLC22A6SLC22A8TYR | |
| SCHEMBL3200412 | 0.67 | ESR1 (0.50) | ESR1ESR2 | |
| SCHEMBL29272829 | 0.66 | ESR1 (0.49) | ESR1ESR2PSMB5KDM4EGAA | |
| SCHEMBL6830345 | 0.63 | ESR1 (1.00) | ESR1ESR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004073612-A2 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO. INC. (US) | 2004-09-02 | — | — | WO | claimed |