Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 2/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 5/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.35 |
| ▸ | S100A4 | P26447 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
| ▸ | PPOX | P50336 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
| ▸ | PTAFR | P25105 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6826687 | 0.77 | ALDH1A1 (0.40) | HSP90AA1ALDH1A1 | |
| SCHEMBL6826934 | 0.74 | KDM4E (0.46) | SRD5A1SRD5A2ALDH1A1NOTUM | |
| SCHEMBL29544 | 0.67 | METAP1 (0.39) | METAP1SRD5A1SRD5A2S100A4HTT | |
| SCHEMBL3870099 | 0.67 | METAP1 (0.36) | METAP1SRD5A1SRD5A2S100A4HTT | |
| SCHEMBL16371580 | 0.62 | PTGS2 (0.43) | SRD5A1SRD5A2S100A4TDP1ALDH1A1 | |
| SCHEMBL31757069 | 0.62 | PTGS2 (0.43) | SRD5A1SRD5A2S100A4TDP1ALDH1A1 | |
| SCHEMBL19775784 | 0.62 | CES1 (0.39) | HTTALDH1A1MAPT | |
| SCHEMBL17430186 | 0.62 | CYP2A6 (0.45) | S100A4TDP1ALDH1A1MAPT | |
| SCHEMBL13039531 | 0.61 | ALDH1A1 (0.54) | HTTTDP1ALDH1A1MAPT | |
| SCHEMBL1758631 | 0.61 | MEN1 (0.50) | TDP1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6737547-B1 | Compositions containing and methods of using N-acyl-1H-aminoindenes | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2004-05-18 | — | — | US | claimed |
| WO-2000038673-A1 | COMPOSITIONS CONTAINING AND METHODS OF USING N-ACYL-1H-AMINOINDENES | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2000-07-06 | — | — | WO | claimed |
| US-6737547-B1 | Compositions containing and methods of using N-acyl-1H-aminoindenes | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2004-05-18 | — | — | US | disclosed |
| WO-2000038673-A1 | COMPOSITIONS CONTAINING AND METHODS OF USING N-ACYL-1H-AMINOINDENES | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2000-07-06 | — | — | WO | disclosed |