Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.51 |
| ▸ | ACACB | O00763 | 2/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.49 |
| ▸ | CKS1B | P61024 | 1/20 | 0.48 |
| ▸ | SKP1 | P63208 | 1/20 | 0.48 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.45 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.45 |
| ▸ | ITGAL | P20701 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | RBP4 | P02753 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 2/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6830336 | 1.00 | SYK (0.51) | SYKACACBPDE10ACKS1BSKP1 | |
| SCHEMBL7386934 | 0.86 | BTK (0.51) | SYKPDE10ACKS1BSKP1SKP2 | |
| SCHEMBL22499976 | 0.83 | SYK (0.51) | SYKACACBPDE10ACKS1BSKP1 | |
| SCHEMBL18239342 | 0.83 | GPR119 (0.55) | SYKPDE10ACKS1BSKP1SKP2 | |
| SCHEMBL1351338 | 0.82 | ACACB (0.52) | SYKACACBPDE10ACKS1BSKP1 | |
| SCHEMBL1351335 | 0.82 | ACACB (0.52) | SYKACACBPDE10ACKS1BSKP1 | |
| SCHEMBL29689898 | 0.82 | ACACB (0.52) | SYKACACBPDE10ACKS1BSKP1 | |
| SCHEMBL18901626 | 0.82 | PKM (0.46) | SYKACACBCKS1BSKP1SKP2 | |
| SCHEMBL22499860 | 0.81 | CCNC (0.57) | SYKPDE10ACKS1BSKP1SKP2 | |
| SCHEMBL29689849 | 0.81 | CCNC (0.57) | SYKPDE10ACKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024710-A1 | UREA COMPOUNDS ACTIVE AS VANILLOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN | GLAXO GROUP LIMITED (GB) | 2004-03-25 | — | — | WO | disclosed |