Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 20/20 | 0.66 |
| ▸ | HTR1D | P28221 | 19/20 | 0.66 |
| ▸ | HTR1B | P28222 | 18/20 | 0.66 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.51 |
| ▸ | DRD2 | P14416 | 4/20 | 0.51 |
| ▸ | HTR2A | P28223 | 4/20 | 0.51 |
| ▸ | HTR7 | P34969 | 4/20 | 0.51 |
| ▸ | DRD3 | P35462 | 4/20 | 0.51 |
| ▸ | HTR2B | P41595 | 3/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6829012 | 0.86 | HTR1A (0.82) | HTR1AHTR1DHTR1BADRB1DRD2 | |
| SCHEMBL5342149 | 0.83 | HTR1A (0.59) | HTR1AHTR1DHTR1BADRB1DRD2 | |
| SCHEMBL6831990 | 0.79 | HTR1A (0.49) | HTR1AHTR1DHTR1BADRB1DRD2 | |
| SCHEMBL14564986 | 0.77 | HTR1A (0.82) | HTR1AHTR1DHTR1BADRB1DRD2 | |
| SCHEMBL5345621 | 0.76 | HTR1A (0.62) | HTR1AHTR1DHTR1BADRB1DRD2 | |
| SCHEMBL6834118 | 0.76 | HTR1D (1.00) | HTR1AHTR1DHTR1BADRB1DRD2 | |
| SCHEMBL5369281 | 0.76 | HTR1A (0.53) | HTR1AHTR1DHTR1BADRB1DRD2 | |
| SCHEMBL14565038 | 0.74 | HTR1A (1.00) | HTR1AHTR1DHTR1BADRB1DRD2 | |
| SCHEMBL5342124 | 0.72 | HTR1A (0.74) | HTR1AHTR1DHTR1BADRB1DRD2 | |
| SCHEMBL5364338 | 0.72 | HTR1A (0.54) | HTR1AHTR1DHTR1BADRB1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004099198-A1 | BENZOXAZINONE DERIVATIVES HAVING AFFINITY FOR 5- HT RECEPTORS, THEIR PREPARATION AND USE | GLAXO GROUP LIMITED (GB) | 2004-11-18 | — | — | WO | claimed |
| WO-2004099198-A1 | BENZOXAZINONE DERIVATIVES HAVING AFFINITY FOR 5- HT RECEPTORS, THEIR PREPARATION AND USE | GLAXO GROUP LIMITED (GB) | 2004-11-18 | — | — | WO | disclosed |