Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 20/20 | 0.49 |
| ▸ | HTR1D | P28221 | 20/20 | 0.49 |
| ▸ | HTR1B | P28222 | 20/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6829014 | 0.85 | HTR1A (0.51) | HTR1AHTR1DHTR1BSLC6A4ADRB1 | |
| SCHEMBL6831989 | 0.79 | HTR1A (0.66) | HTR1AHTR1DHTR1BSLC6A4ADRB1 | |
| SCHEMBL6834120 | 0.77 | HTR1D (0.62) | HTR1AHTR1DHTR1BSLC6A4ADRB1 | |
| SCHEMBL5214741 | 0.70 | HTR1D (0.60) | HTR1AHTR1DHTR1BSLC6A4ADRB1 | |
| SCHEMBL6832017 | 0.68 | HTR1D (0.62) | HTR1AHTR1DHTR1BSLC6A4ADRB1 | |
| SCHEMBL6829012 | 0.68 | HTR1A (0.82) | HTR1AHTR1DHTR1BSLC6A4ADRB1 | |
| SCHEMBL6828923 | 0.66 | HTR1A (0.64) | HTR1AHTR1DHTR1BSLC6A4ADRB1 | |
| Hydrochloric Acid SCHEMBL6831442 | 0.65 | HTR1A (0.41) | HTR1AHTR1DHTR1BSLC6A4ADRB1 | |
| SCHEMBL6833677 | 0.65 | HTR1A (0.61) | HTR1AHTR1DHTR1BSLC6A4ADRB1 | |
| SCHEMBL5342149 | 0.64 | HTR1A (0.59) | HTR1AHTR1DHTR1BSLC6A4ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004099198-A1 | BENZOXAZINONE DERIVATIVES HAVING AFFINITY FOR 5- HT RECEPTORS, THEIR PREPARATION AND USE | GLAXO GROUP LIMITED (GB) | 2004-11-18 | — | — | WO | claimed |
| WO-2004099198-A1 | BENZOXAZINONE DERIVATIVES HAVING AFFINITY FOR 5- HT RECEPTORS, THEIR PREPARATION AND USE | GLAXO GROUP LIMITED (GB) | 2004-11-18 | — | — | WO | disclosed |