Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.64 |
| ▸ | IDO1 | P14902 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | MAOB | P27338 | 3/20 | 0.61 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MAOA | P21397 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA4 | P22748 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10099725 | 0.86 | GAA (0.83) | GAAIDO1MEN1KMT2AMAPK1 | |
| SCHEMBL469849 | 0.82 | NOX1 (0.84) | GAAIDO1MEN1KMT2AMAPK1 | |
| SCHEMBL6302055 | 0.78 | GAA (0.64) | GAAIDO1MEN1KMT2AMAPK1 | |
| SCHEMBL18031169 | 0.78 | GAA (1.00) | GAAIDO1MEN1KMT2AMAPK1 | |
| SCHEMBL6302052 | 0.78 | GAA (0.64) | GAAIDO1MEN1KMT2AMAPK1 | |
| SCHEMBL10710275 | 0.78 | NOX1 (0.85) | GAAIDO1MEN1KMT2AMAPK1 | |
| SCHEMBL455548 | 0.78 | IDO1 (1.00) | GAAIDO1MEN1KMT2AMAPK1 | |
| SCHEMBL20560273 | 0.77 | GAA (0.57) | GAAIDO1MEN1KMT2AMAPK1 | |
| SCHEMBL2875258 | 0.77 | ALDH1A1 (0.73) | GAAMEN1KMT2ALMNAMAPT | |
| SCHEMBL7658710 | 0.77 | MEN1 (0.68) | GAAIDO1MEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1467981-A1 | 4(HETERO-) ARYL SUBSTITUTED (THIA-/OXA-/PYRA) ZOLES FOR INHIBITION OF TIE-2 | Kylix Pharmaceuticals B.V. (NL) | 2004-10-20 | — | — | EP | disclosed |
| WO-2003062215-A1 | 4(HETERO-) ARYL SUBSTITUTED (THIA-/OXA-/PYRA) ZOLES FOR INHIBITION OF TIE-2 | KYLIX PHARMACEUTICALS B.V. (NL) | 2003-07-31 | — | — | WO | disclosed |