Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.40 |
| ▸ | CDC7 | O00311 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | F3 | P13726 | 1/20 | 0.37 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1327240 | 0.81 | SIRT3 (0.59) | SIRT3TDP1ALDH1A1KMT2ASLC22A12 | |
| SCHEMBL1328542 | 0.77 | SIRT3 (0.54) | SIRT3TDP1ALDH1A1KMT2ASLC22A12 | |
| SCHEMBL6781811 | 0.75 | SIRT1 (0.55) | ALDH1A1KMT2AKDM4EHTTCA12 | |
| SCHEMBL740928 | 0.74 | TDP1 (0.51) | SIRT3TDP1ALDH1A1SLC22A12CDC7 | |
| SCHEMBL6215853 | 0.74 | SIRT3 (0.59) | SIRT3TDP1ALDH1A1KMT2ACDC7 | |
| SCHEMBL16703743 | 0.73 | HASPIN (0.40) | TDP1ALDH1A1KMT2ASLC22A12KDM4E | |
| SCHEMBL5087701 | 0.72 | SIRT1 (0.65) | SIRT3TDP1SLC22A12CDC7KDM4E | |
| SCHEMBL1687197 | 0.72 | TDP1 (0.67) | SIRT3TDP1ALDH1A1KMT2ACDC7 | |
| SCHEMBL1330970 | 0.72 | TDP1 (0.67) | SIRT3TDP1ALDH1A1KMT2ACDC7 | |
| SCHEMBL20196932 | 0.71 | KMT2A (0.41) | TDP1ALDH1A1KMT2AKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004087669-A1 | NOVEL QUINOLINE, TETRAHYDROQUINAZOLINE, AND PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMACEUTICAL CO. LTD. (JP) | 2004-10-14 | — | — | WO | disclosed |