Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.51 |
| ▸ | GAA | P10253 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25403743 | 0.80 | RAB9A (0.60) | GRM5ALDH1A1GAAMAPTHPGD | |
| SCHEMBL1514097 | 0.78 | GRM5 (0.58) | GRM5ALDH1A1GAAMAPTHPGD | |
| SCHEMBL2578961 | 0.77 | ALDH1A1 (0.71) | GRM5ALDH1A1GAAMAPTHPGD | |
| SCHEMBL421678 | 0.77 | ALDH1A1 (0.69) | GRM5ALDH1A1GAAMAPTHPGD | |
| SCHEMBL25403220 | 0.77 | ALDH1A1 (0.69) | GRM5ALDH1A1GAAMAPTHPGD | |
| SCHEMBL3028344 | 0.73 | GRM5 (0.50) | GRM5ALDH1A1GAAMAPTHPGD | |
| SCHEMBL20557455 | 0.72 | ALDH1A1 (0.60) | GRM5ALDH1A1GAAMAPTHPGD | |
| SCHEMBL31038670 | 0.72 | ALDH1A1 (0.54) | GRM5ALDH1A1GAAMAPTHPGD | |
| SCHEMBL30028584 | 0.72 | ALDH1A1 (0.60) | GRM5ALDH1A1GAAMAPTHPGD | |
| SCHEMBL247331 | 0.72 | ALDH1A1 (0.54) | GRM5ALDH1A1GAAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1467981-A1 | 4(HETERO-) ARYL SUBSTITUTED (THIA-/OXA-/PYRA) ZOLES FOR INHIBITION OF TIE-2 | Kylix Pharmaceuticals B.V. (NL) | 2004-10-20 | — | — | EP | disclosed |
| WO-2003062215-A1 | 4(HETERO-) ARYL SUBSTITUTED (THIA-/OXA-/PYRA) ZOLES FOR INHIBITION OF TIE-2 | KYLIX PHARMACEUTICALS B.V. (NL) | 2003-07-31 | — | — | WO | disclosed |