Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | TYR | P14679 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | ABAT | P80404 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27517715 | 0.98 | ALDH1A1 (0.54) | ALDH1A1TP53TYRTSHRTAS2R38 | |
| SCHEMBL16193023 | 0.84 | MAPT (0.54) | ALDH1A1TAS2R38HSD17B10CYP3A4CYP2C19 | |
| SCHEMBL16024387 | 0.84 | ALDH1A1 (0.58) | ALDH1A1TP53TYRTSHRTAS2R38 | |
| SCHEMBL725810 | 0.83 | ALDH1A1 (0.75) | ALDH1A1TP53TYRTSHRTAS2R38 | |
| SCHEMBL28701548 | 0.83 | ALDH1A1 (0.56) | ALDH1A1TP53TYRTSHRTAS2R38 | |
| SCHEMBL2300811 | 0.81 | GRIN2D (0.58) | ALDH1A1TP53TYRTSHRTAS2R38 | |
| SCHEMBL27295444 | 0.80 | KMT2A (0.59) | ALDH1A1TP53TYRTSHRTAS2R38 | |
| SCHEMBL1893556 | 0.79 | ALDH1A1 (0.52) | ALDH1A1TP53TYRTSHRTAS2R38 | |
| SCHEMBL28253803 | 0.79 | CA2 (0.53) | ALDH1A1ALOX12GAAMAPTPLAU | |
| SCHEMBL27602582 | 0.79 | IDO1 (0.60) | ALDH1A1KMT2AGAAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1572299-A | Medicine for improving excretion capacity of bladder | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2005-02-02 | — | — | CN | claimed |
| CN-107629022-A | A kind of Trimethoprim and its preparation method and purposes | 上海医药工业研究院 | 2018-01-26 | — | — | CN | disclosed |
| CN-107625766-A | A kind of thiazole compound is used as the purposes of Trimethoprim | 上海医药工业研究院 | 2018-01-26 | — | — | CN | disclosed |
| CN-107266388-A | A kind of aminothiazole analog derivative | 重庆大学 | 2017-10-20 | — | — | CN | disclosed |
| CN-104093701-B | Separation method | 旭化成株式会社 | 2017-05-03 | — | — | CN | disclosed |
| CN-101129295-B | There is the binary initiator system of good storage stability and especially suitable for acidic system | HERAEUS KULZER GMBH (DE) | 2016-02-10 | — | — | CN | disclosed |
| CN-104093701-A | Separation method | ASAHI KASEI CHEMICALS CORP | 2014-10-08 | — | — | CN | disclosed |
| CN-102367240-A | 1,2,3-thiadiazole mother ring-contained iminothiazolone compounds, intermediate thereof, and preparation methods and applications of compound and intermediate | UNIV EAST CHINA SCIENCE & TECH | 2012-03-07 | — | — | CN | disclosed |
| CN-101277692-A | Use of thiazole derivatives and analogues in the treatment of cancer | BETAGENON AB (SE) | 2008-10-01 | — | — | CN | disclosed |
| CN-100420678-C | Cyclization process for substituted benzothiazole derivatives | HOFFMANN LA ROCHE (CH) | 2008-09-24 | — | — | CN | disclosed |
| CN-101237866-A | Use of thiazole derivatives and analogues in the treatment of cancer | BETAGENON AB (SE) | 2008-08-06 | — | — | CN | disclosed |
| CN-101129295-A | 2-component initiator system (amine free) with storage stability and especially suitable for acidic systems | HERAEUS KULZER GMBH (DE) | 2008-02-27 | — | — | CN | disclosed |
| CN-1738808-A | Cyclization process for substituted benzothiazole derivatives | HOFFMANN LA ROCHE (CH) | 2006-02-22 | — | — | CN | disclosed |
| CN-1572299-A | Medicine for improving excretion capacity of bladder | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2005-02-02 | — | — | CN | disclosed |
| EP-1467981-A1 | 4(HETERO-) ARYL SUBSTITUTED (THIA-/OXA-/PYRA) ZOLES FOR INHIBITION OF TIE-2 | Kylix Pharmaceuticals B.V. (NL) | 2004-10-20 | — | — | EP | disclosed |
| WO-2003062215-A1 | 4(HETERO-) ARYL SUBSTITUTED (THIA-/OXA-/PYRA) ZOLES FOR INHIBITION OF TIE-2 | KYLIX PHARMACEUTICALS B.V. (NL) | 2003-07-31 | — | — | WO | disclosed |
| CN-1035253-C | Pyranyl cyanoguanidine derivatives | SQUIBB & SONS INC (US) | 1997-06-25 | — | — | CN | disclosed |
| CN-1064272-A | PYRANYL CYANOGUANIDINE DERIVATIVES | SQUIBB & SONS INC (US) | 1992-09-09 | — | — | CN | disclosed |
| CN-86103798-A | The preparation method of N-phenyl-4-phenyl-1-piperazine carbonamidine and their purposes as anti-arrhythmic | — | 1987-06-10 | — | — | CN | disclosed |