Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 known ✓ | P49768 | 2/20 | 0.46 |
| ▸ | PSEN2 known ✓ | P49810 | 2/20 | 0.46 |
| ▸ | APH1B known ✓ | Q8WW43 | 2/20 | 0.46 |
| ▸ | NCSTN known ✓ | Q92542 | 2/20 | 0.46 |
| ▸ | APH1A known ✓ | Q96BI3 | 2/20 | 0.46 |
| ▸ | PSENEN known ✓ | Q9NZ42 | 2/20 | 0.46 |
| ▸ | VCP | P55072 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 8/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7040098 | 0.99 | VCP (0.69) | VCPMAPTKDM4ENPSR1MAPK1 | |
| SCHEMBL12297322 | 0.89 | ALOX5 (0.67) | VCPMAPTKDM4ENPSR1MAPK1 | |
| SCHEMBL12298202 | 0.85 | CYP1A2 (0.61) | VCPMAPTMAPK1MEN1KMT2A | |
| SCHEMBL12298062 | 0.85 | MEN1 (0.67) | MAPTMAPK1MEN1KMT2ARAB9A | |
| SCHEMBL7262430 | 0.83 | VCP (0.78) | VCPMAPTKDM4ENPSR1MAPK1 | |
| SCHEMBL12297990 | 0.83 | MEN1 (0.58) | VCPMAPTMAPK1MEN1KMT2A | |
| SCHEMBL12298081 | 0.83 | ALOX5 (0.68) | VCPMAPTKDM4ENPSR1MAPK1 | |
| SCHEMBL12298178 | 0.83 | MEN1 (0.58) | VCPMAPTNPSR1MAPK1POLB | |
| SCHEMBL12298071 | 0.82 | VCP (0.80) | VCPMAPTKDM4ENPSR1MAPK1 | |
| SCHEMBL7263150 | 0.82 | VCP (0.80) | VCPMAPTKDM4ENPSR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1467981-A1 | 4(HETERO-) ARYL SUBSTITUTED (THIA-/OXA-/PYRA) ZOLES FOR INHIBITION OF TIE-2 | Kylix Pharmaceuticals B.V. (NL) | 2004-10-20 | — | — | EP | disclosed |
| WO-2003062215-A1 | 4(HETERO-) ARYL SUBSTITUTED (THIA-/OXA-/PYRA) ZOLES FOR INHIBITION OF TIE-2 | KYLIX PHARMACEUTICALS B.V. (NL) | 2003-07-31 | — | — | WO | disclosed |