Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.35 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1169569 | 0.86 | CYP2A6 (0.41) | FLT1FLT4KDRGSK3BXDH | |
| SCHEMBL29740345 | 0.86 | CYP2A6 (0.41) | FLT1FLT4KDRGSK3BXDH | |
| SCHEMBL22072190 | 0.81 | MRGPRX4 (0.43) | SETDB1CA1CA2MAPTALDH1A1 | |
| SCHEMBL28575929 | 0.80 | CA1 (0.42) | FLT1FLT4KDRXDHSLC22A12 | |
| SCHEMBL6505737 | 0.77 | MAPK14 (0.45) | GSK3BMEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL6628485 | 0.77 | FLT1 (0.52) | FLT1FLT4KDRXDHSLC22A12 | |
| SCHEMBL27929630 | 0.75 | CYP2A6 (0.39) | CA1CA2ALDH1A1 | |
| SCHEMBL289547 | 0.75 | LRRK2 (0.44) | FLT1FLT4KDRGSK3BXDH | |
| SCHEMBL17109321 | 0.75 | MEN1 (0.44) | FLT1FLT4KDRGSK3BXDH | |
| SCHEMBL646582 | 0.75 | KMT2A (0.49) | MAPTMEN1ALDH1A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120252784-A1 | 2,3,4-BENZOTHIADIAZEPINE-2,2-DIOXIDE DERIVATIVES | EGIS GYOGYSZERGYAR NYILVANOSAN MUEKOEDOE RESZVENYTARSASAG (HU) | 2012-10-04 | — | — | US | disclosed |
| US-20120252784-A1 | 2,3,4-BENZOTHIADIAZEPINE-2,2-DIOXIDE DERIVATIVES | EGIS GYOGYSZERGYAR NYILVANOSAN MUEKOEDOE RESZVENYTARSASAG (HU) | 2012-10-04 | — | — | US | disclosed |
| US-6753433-B2 | CITALOPRAM; HALOGENATING 5-CYANOPHTHALIDE TO FORM 2-(HALOMETHYL)-4-CYANOBENZOYL HALIDE; REACTION WITH P-FLUOROPHENYL- BORANE OR METAL HALIDE; REACTING WITH 3-(DIMETHYLAMINO)PROPYLMETAL HALIDE | ORION CORPORATION, FERMION (FI) | 2004-06-22 | — | — | US | disclosed |
| EP-1355897-A1 | PROCESS FOR THE PREPARATION OF 1-(3-DIMETHYLAMINOPROPYL)-1-(4-FLUOROPHENYL)-1,3-DIHYDROISOBENZOFURAN-5-CARBONITRILE | ORION CORPORATION FERMION (FI) | 2003-10-29 | — | — | EP | disclosed |
| US-20030130527-A1 | Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile | ORION CORPORATION FERMION (FI) | 2003-07-10 | — | — | US | disclosed |
| US-6579993-B2 | Halogenating 5-cyanophthalide to a cyanobenzeneacyl halide derivative reacted with organometallic 4-fluorophenyl halides and 4-fluorophenylboranes to a biphenyl ketone reacted with an organometallic 3-dimethylaminopropyl halide | ORION CORPORATION, FERMION (FI) | 2003-06-17 | — | — | US | disclosed |
| US-20020115872-A1 | Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile | ORION CORPORATION FERMION (FI) | 2002-08-22 | — | — | US | disclosed |
| WO-2002060886-A1 | PROCESS FOR THE PREPARATION OF 1-(3-DIMETHYLAMINOPROPYL)-1-(4-FLUOROPHENYL)-1,3-DIHYDROISOBENZOFURAN-5-CARBONITRILE | ORION CORPORATION, FERMION (FI) | 2002-08-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020115872-A1 | Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile | CYP2F1, CYP4F3, CYP4F2 | FLT1 4066/4885FLT4 4313/4885KDR 4747/4885 |
| US-20030130527-A1 | Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile | CYP2F1, CYP4F3, CYP4F2 | FLT1 4173/4885FLT4 4368/4885KDR 4741/4885 |
| US-20120252784-A1 | 2,3,4-BENZOTHIADIAZEPINE-2,2-DIOXIDE DERIVATIVES | BACE2, BACE1, HTR2C | FLT1 4703/4885FLT4 4100/4885KDR 2771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.