SCHEMBL6835387

SCHEMBL6835387

C=C(Cc1cccc2ccccc12)C(=O)OCC

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.56
TDP1 Q9NUW8 2/20 0.53
KDM4E B2RXH2 1/20 0.51
APOBEC3A P31941 1/20 0.51
APOBEC3G Q9HC16 1/20 0.51
ATM Q13315 1/20 0.49
L3MBTL1 Q9Y468 3/20 0.48
ALDH1A1 P00352 2/20 0.48
HPGD P15428 1/20 0.48
CDC25B P30305 2/20 0.47
SIRT5 Q9NXA8 1/20 0.46
LMNA P02545 1/20 0.45
PKM P14618 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
MAPT P10636 1/20 0.44
MAPK8 P45983 1/20 0.44
MAPK9 P45984 1/20 0.44
MAPK10 P53779 1/20 0.44
CDC25A P30304 1/20 0.44
CDC25C P30307 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7638348 0.85 KMT2A (0.59) KMT2ATDP1KDM4EAPOBEC3AAPOBEC3G
SCHEMBL3826534 0.85 ATM (0.58) KMT2ATDP1ATML3MBTL1SIRT5
SCHEMBL17493303 0.83 KMT2A (0.47) KMT2ATDP1KDM4EAPOBEC3AAPOBEC3G
SCHEMBL845701 0.81 KMT2A (0.62) KMT2ATDP1KDM4EAPOBEC3AAPOBEC3G
SCHEMBL29729685 0.81 KMT2A (0.62) KMT2ATDP1KDM4EAPOBEC3AAPOBEC3G
SCHEMBL7644966 0.81 ALDH1A1 (0.49) KMT2AKDM4EALDH1A1LMNASMN1; SMN2
SCHEMBL27953552 0.80 AKR1B1 (0.50) KMT2AALDH1A1PKMSMN1; SMN2MAPT
SCHEMBL30716618 0.80 KMT2A (0.54) KMT2ATDP1KDM4EAPOBEC3AAPOBEC3G
SCHEMBL20897263 0.80 KMT2A (0.54) KMT2ATDP1KDM4EAPOBEC3AAPOBEC3G
SCHEMBL7326228 0.79 EPHX1 (0.47) KMT2ATDP1KDM4EATML3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6753125-B2 SUCH AS A 1-NAPHTHALENEMETHYL ACRYLATE COPOLYMER; PHOTORESIST WITH RESISTANCE TO DRY ETCHING; FOR PHOTOLITHOGRAPHY SAMSUNG ELECTRONICS, CO. LTD (KR) 2004-06-22 US disclosed
US-20020076641-A1 Photosensitive polymer having fused aromatic ring and photoresist composition containing the same SAMSUNG ELECTRONICS CO., LTD. 2002-06-20 US disclosed
EP-0309766-B1 N-acylamino acid derivatives and their use BANYU PHARMA CO LTD (JP) 1998-04-15 EP disclosed
US-5506356-A RENIN INHIBITORS; HYPOTENSIVE AGENTS BANYU PHARMACEUTICAL CO., LTD. (JP) 1996-04-09 US disclosed
US-5481036-A RENIN INHIBITORS, HYPOTENSIVE AGENTS BANYU PHARMACEUTICAL CO., LTD. (JP) 1996-01-02 US disclosed
EP-0377139-B1 N-substituted acylamino acid compounds, process for their production and their use BANYU PHARMA CO LTD (JP) 1995-07-12 EP disclosed
US-5424309-A Hypotensive agents BANYU PHARMACEUTICAL CO., LTD. (JP) 1995-06-13 US disclosed
US-5393875-A Hypotensive, cardiotonic and antiischemic agents HOFFMANN-LA ROCHE INC. (US) 1995-02-28 US disclosed
US-5319082-A N-acylamino acid derivatives BANYU PHARMACEUTICAL CO., LTD. (JP) 1994-06-07 US disclosed
US-5240924-A Dipeptide hypotensives BANYU PHARMACEUTICAL CO., LTD. (JP) 1993-08-31 US disclosed
US-5122523-A Hypotensive agents BANYU PHARMACEUTICAL CO., LTD. (JP) 1992-06-16 US disclosed
EP-0377139-A1 N-substituted acylamino acid compounds, process for their production and their use Banyu Pharmaceutical Co., Ltd. (JP) 1990-07-11 EP disclosed
EP-0309766-A2 N-acylamino acid derivatives and their use BANYU PHARMACEUTICAL CO., LTD. (JP) 1989-04-05 EP disclosed