Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4B | O94953 | 2/20 | 0.44 |
| ▸ | KDM5C | P41229 | 2/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.44 |
| ▸ | KDM6B | O15054 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.44 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6841110 | 0.98 | LMNA (0.46) | LMNAKDM4BKDM5CKDM5BKDM6B | |
| SCHEMBL15623071 | 0.80 | LMNA (0.43) | LMNAALDH1A1MAPTMAPK14MAPK13 | |
| SCHEMBL26840411 | 0.77 | KDM4E (0.53) | LMNAALDH1A1MAPTNPC1MAPK14 | |
| SCHEMBL21067987 | 0.77 | HSP90AA1 (0.55) | LMNAKDM4BKDM5CKDM5BKDM6B | |
| SCHEMBL31093398 | 0.74 | LMNA (0.48) | LMNAALDH1A1MAPTNPC1MAPK14 | |
| SCHEMBL1888770 | 0.73 | CDK4 (0.52) | LMNAALDH1A1MAPTNPC1HSD17B10 | |
| SCHEMBL29318736 | 0.72 | LMNA (0.36) | LMNACCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL30995396 | 0.72 | LMNA (0.36) | LMNACCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL6839924 | 0.72 | LMNA (0.46) | LMNAALDH1A1MAPTHSD17B10MAPK14 | |
| SCHEMBL28146832 | 0.72 | LMNA (0.47) | LMNAALDH1A1NPC1MAPK14MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040181066-A1 | Tyrosine kinase inhibitors | FRALEY MARK E (US) | 2004-09-16 | — | — | US | disclosed |
| WO-2003011838-A1 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2003-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040181066-A1 | Tyrosine kinase inhibitors | ERBB2, TYRO3, TIE1 | LMNA 3751/4885KDM4B 3350/4885KDM5C 2852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.