Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 10/20 | 0.65 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.65 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | THPO | P40225 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9840392 | 0.84 | ADORA2B (0.81) | ADORA2BADORA2AADORA1KDM4EHSD17B10 | |
| SCHEMBL10616171 | 0.83 | ADORA2B (0.68) | ADORA2BADORA2AADORA1KDM4EHSD17B10 | |
| SCHEMBL9765918 | 0.83 | ADORA2B (0.85) | ADORA2BADORA2AADORA1KDM4EHSD17B10 | |
| 8-Phenyl Theophylline SCHEMBL516432 | 0.80 | ADORA2A (1.00) | ADORA2BADORA2AADORA1KDM4EHSD17B10 | |
| SCHEMBL9765879 | 0.76 | ADORA2B (0.85) | ADORA2BADORA2AADORA1KDM4EHSD17B10 | |
| SCHEMBL661108 | 0.75 | ADORA2B (1.00) | ADORA2BADORA2AADORA1KDM4EHSD17B10 | |
| SCHEMBL1321894 | 0.74 | ADORA2B (1.00) | ADORA2BADORA2AADORA1KDM4EHSD17B10 | |
| SCHEMBL1320226 | 0.73 | ADORA2B (1.00) | ADORA2BADORA2AADORA1KDM4EHSD17B10 | |
| SCHEMBL9765909 | 0.73 | ADORA2B (1.00) | ADORA2BADORA2AADORA1KDM4EHSD17B10 | |
| SCHEMBL27140351 | 0.72 | ADORA2B (0.97) | ADORA2BADORA2AADORA1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004058170-A9 | METHODS FOR TREATING MALARIA BY MODULATION OF G PROTEIN FUNCTION | UNIV NORTHWESTERN (US) | 2004-08-19 | — | — | WO | disclosed |
| WO-2004058170-A2 | METHODS FOR TREATING MALARIA BY MODULATION OF G PROTEIN FUNCTION | NORTHWESTERN UNIVERSITY (US) | 2004-07-15 | — | — | WO | disclosed |
| US-5658889-A | ADMINISTERING 5-AMINO-4-IMIDAZLECARBOXAMIDE RIBOSIDE WHICH BINDS ADENOSINE MONOPHOSPHATE SITE OF FRUCTOSE-1,6-DIPHOSPHATASE | GENSIA PHARMACEUTICALS, INC. (US) | 1997-08-19 | — | — | US | disclosed |
| EP-0427799-B1 | METHOD AND COMPOUNDS FOR AICA RIBOSIDE DELIVERY AND FOR LOWERING BLOOD GLUCOSE | GENSIA PHARMA (US) | 1994-11-30 | — | — | EP | disclosed |
| EP-0427799-A4 | METHOD AND COMPOUNDS FOR AICA RIBOSIDE DELIVERY AND FOR LOWERING BLOOD GLUCOSE | — | 1991-07-24 | — | — | EP | disclosed |
| EP-0427799-A1 | METHOD AND COMPOUNDS FOR AICA RIBOSIDE DELIVERY AND FOR LOWERING BLOOD GLUCOSE. | GENSIA PHARMA (US) | 1991-05-22 | — | — | EP | disclosed |
| WO-1990009163-A2 | METHOD AND COMPOUNDS FOR AICA RIBOSIDE DELIVERY AND FOR LOWERING BLOOD GLUCOSE | GENSIA PHARMACEUTICALS, INC. (US) | 1990-08-23 | — | — | WO | disclosed |