Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.37 |
| ▸ | MMP2 | P08253 | 3/20 | 0.36 |
| ▸ | MMP1 | P03956 | 2/20 | 0.36 |
| ▸ | MMP3 | P08254 | 2/20 | 0.36 |
| ▸ | MMP7 | P09237 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6672 | 0.83 | TP53 (0.37) | ALDH1A1LMNARAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL18597896 | 0.80 | HPGD (0.39) | ALDH1A1LMNARAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL6835 | 0.80 | HPGD (0.39) | ALDH1A1LMNARAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL6734 | 0.76 | ADRB2 (0.38) | ALDH1A1LMNARAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL6943 | 0.76 | EPHX1 (0.35) | ALDH1A1LMNARAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL1925 | 0.76 | LPAR1 (0.36) | ALDH1A1LMNARAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL1909 | 0.76 | LPAR1 (0.36) | ALDH1A1LMNARAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL2087 | 0.76 | EPHX1 (0.35) | ALDH1A1LMNARAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL2761302 | 0.76 | RAB9A (0.42) | ALDH1A1LMNARAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL2836880 | 0.76 | RAB9A (0.42) | ALDH1A1LMNARAB9ASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |