Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 8/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.67 |
| ▸ | AR | P10275 | 3/20 | 0.67 |
| ▸ | F2 | P00734 | 1/20 | 0.67 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 4/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | USP2 | O75604 | 2/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | SHBG | P04278 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | HRH2 | P25021 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6836062 | 1.00 | PGR (0.67) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL11272818 | 1.00 | PGR (0.67) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL6836061 | 1.00 | PGR (0.67) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL11686743 | 0.92 | CYP3A4 (0.64) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL11686756 | 0.92 | CYP3A4 (0.64) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL11878275 | 0.91 | CYP3A4 (0.73) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL1371249 | 0.91 | CYP3A4 (0.73) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL11878266 | 0.91 | CYP3A4 (0.73) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL6836230 | 0.91 | CYP3A4 (0.73) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL6836229 | 0.91 | CYP3A4 (0.73) | PGRCYP3A4ARF2NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828120-B2 | Preparation of 11 beta ,17 alpha ,21- trihydroxy-6 alpha -methylpregna-1,4-diene-3,20-dione 21-acetate; obtain chemical intermediates, incubate reaction mix and enzymes, recover product | PHARMACIA AND UPJOHN COMPANY | 2004-12-07 | — | — | US | claimed |
| US-20040006240-A1 | Process to prepare 11beta,17alpha ,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-acetate | PHARMACIA & UPJOHN COMPANY | 2004-01-08 | — | — | US | claimed |
| US-20030044885-A1 | Process to prepare 11beta, 17alpha,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-acetate | CRIA, INC. | 2003-03-06 | — | — | US | claimed |
| US-20030013900-A1 | Process to prepare11beta,17alpha, 21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-acetate | PHARMACIA & UPJOHN COMPANY | 2003-01-16 | — | — | US | claimed |
| US-6828120-B2 | Preparation of 11 beta ,17 alpha ,21- trihydroxy-6 alpha -methylpregna-1,4-diene-3,20-dione 21-acetate; obtain chemical intermediates, incubate reaction mix and enzymes, recover product | PHARMACIA AND UPJOHN COMPANY | 2004-12-07 | — | — | US | disclosed |
| US-20040006240-A1 | Process to prepare 11beta,17alpha ,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-acetate | PHARMACIA & UPJOHN COMPANY | 2004-01-08 | — | — | US | disclosed |
| US-20030044885-A1 | Process to prepare 11beta, 17alpha,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-acetate | CRIA, INC. | 2003-03-06 | — | — | US | disclosed |
| US-20030013900-A1 | Process to prepare11beta,17alpha, 21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-acetate | PHARMACIA & UPJOHN COMPANY | 2003-01-16 | — | — | US | disclosed |
| EP-0754701-B1 | NOVEL PROGESTERONE COMPOUND AND USE THEREOF | MEIJI MILK PROD CO LTD (JP) | 1998-08-12 | — | — | EP | disclosed |
| US-5693629-A | 9A-FLUORO-6A-METHYLPROGESTERONE DERIVATIVES AS ANGIOGENESIS INHIBITORS; ANTITUMOR AND -CARCINOGENIC AGENTS; DIABETIC RETINITIS; RHEUMATISM | MEIJI MILK PRODUCTS CO., LTD. (JP) | 1997-12-02 | — | — | US | disclosed |
| EP-0754701-A1 | NOVEL PROGESTERONE COMPOUND AND USE THEREOF | MEIJI MILK PRODUCTS COMPANY LIMITED (JP) | 1997-01-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030013900-A1 | Process to prepare11beta,17alpha, 21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-acetate | CYP17A1, CYP51A1, CYP4A11 | PGR 447/4885CYP3A4 102/4885AR 171/4885 |
| US-20030044885-A1 | Process to prepare 11beta, 17alpha,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-acetate | CYP17A1, CYP51A1, HSD17B11 | PGR 339/4885CYP3A4 86/4885AR 134/4885 |
| US-20040006240-A1 | Process to prepare 11beta,17alpha ,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-acetate | CYP17A1, CYP51A1, HSD17B11 | PGR 448/4885CYP3A4 96/4885AR 157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.