Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6836620 | 0.85 | HTT (0.47) | ALDH1A1HTTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL7145873 | 0.83 | HTT (0.48) | ALDH1A1HTTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL6836621 | 0.81 | HTT (0.50) | ALDH1A1HTTSMN1; SMN2LMNANPC1 | |
| SCHEMBL6837934 | 0.81 | HTT (0.46) | ALDH1A1HTTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL6837509 | 0.80 | HTT (0.51) | ALDH1A1HTTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL6837936 | 0.80 | SMN1; SMN2 (0.49) | ALDH1A1HTTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL6837894 | 0.80 | NPC1 (0.50) | ALDH1A1HTTSMN1; SMN2LMNANPC1 | |
| SCHEMBL6833326 | 0.79 | NPC1 (0.47) | ALDH1A1HTTSMN1; SMN2LMNANPC1 | |
| SCHEMBL6833325 | 0.79 | NPC1 (0.47) | ALDH1A1HTTSMN1; SMN2LMNANPC1 | |
| SCHEMBL6833183 | 0.78 | HTT (0.49) | ALDH1A1HTTSMN1; SMN2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716987-B1 | PHOSPHODIESTERASE IV INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2004-04-06 | — | — | US | disclosed |
| US-6514996-B2 | Derivatives of benzofuran or benzodioxole | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2003-02-04 | — | — | US | disclosed |