Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6837936 | 0.92 | SMN1; SMN2 (0.49) | HTTSMN1; SMN2NPSR1HSD17B10MEN1 | |
| SCHEMBL6833325 | 0.87 | NPC1 (0.47) | HTTSMN1; SMN2NPSR1HSD17B10MEN1 | |
| SCHEMBL6833326 | 0.87 | NPC1 (0.47) | HTTSMN1; SMN2NPSR1HSD17B10MEN1 | |
| SCHEMBL6836621 | 0.85 | HTT (0.50) | HTTSMN1; SMN2NPSR1HSD17B10MEN1 | |
| SCHEMBL6944133 | 0.85 | EPHX2 (0.45) | HTTSMN1; SMN2NPSR1HSD17B10MEN1 | |
| SCHEMBL6836624 | 0.85 | ALDH1A1 (0.45) | HTTSMN1; SMN2NPSR1HSD17B10MEN1 | |
| SCHEMBL6837509 | 0.84 | HTT (0.51) | HTTSMN1; SMN2NPSR1HSD17B10MEN1 | |
| SCHEMBL6837621 | 0.82 | LMNA (0.49) | HTTSMN1; SMN2NPSR1HSD17B10MEN1 | |
| SCHEMBL6837619 | 0.82 | LMNA (0.49) | HTTSMN1; SMN2NPSR1HSD17B10MEN1 | |
| SCHEMBL6837620 | 0.81 | SMN1; SMN2 (0.53) | HTTSMN1; SMN2NPSR1HSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716987-B1 | PHOSPHODIESTERASE IV INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2004-04-06 | — | — | US | disclosed |
| US-6514996-B2 | Derivatives of benzofuran or benzodioxole | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2003-02-04 | — | — | US | disclosed |