Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.52 |
| ▸ | RAB9A | P51151 | 12/20 | 0.52 |
| ▸ | NPC1 | O15118 | 10/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | PKM | P14618 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.49 |
| ▸ | HPGD | P15428 | 8/20 | 0.49 |
| ▸ | GLA | P06280 | 7/20 | 0.49 |
| ▸ | GAA | P10253 | 7/20 | 0.49 |
| ▸ | TP53 | P04637 | 5/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.49 |
| ▸ | RELA | Q04206 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6836635 | 1.00 | ALDH1A1 (0.52) | ALDH1A1KDM4ERAB9ANPC1L3MBTL1 | |
| SCHEMBL7480493 | 0.79 | ALDH1A1 (0.59) | ALDH1A1KDM4ERAB9ANPC1L3MBTL1 | |
| SCHEMBL7480500 | 0.79 | ALDH1A1 (0.59) | ALDH1A1KDM4ERAB9ANPC1L3MBTL1 | |
| SCHEMBL8550750 | 0.77 | KDM4E (0.64) | ALDH1A1KDM4ERAB9ANPC1L3MBTL1 | |
| SCHEMBL6583386 | 0.77 | KDM4E (0.64) | ALDH1A1KDM4ERAB9ANPC1L3MBTL1 | |
| SCHEMBL6583378 | 0.77 | KDM4E (0.64) | ALDH1A1KDM4ERAB9ANPC1L3MBTL1 | |
| SCHEMBL6835941 | 0.77 | ALDH1A1 (0.56) | ALDH1A1KDM4ERAB9ANPC1L3MBTL1 | |
| SCHEMBL6835939 | 0.77 | ALDH1A1 (0.56) | ALDH1A1KDM4ERAB9ANPC1L3MBTL1 | |
| SCHEMBL6836874 | 0.75 | ALDH1A1 (0.57) | ALDH1A1KDM4ERAB9ANPC1L3MBTL1 | |
| SCHEMBL6836872 | 0.75 | ALDH1A1 (0.57) | ALDH1A1KDM4ERAB9ANPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040181062-A1 | Benzimidazole cyclooxygenase-2 inhibitor | PFIZER INC | 2004-09-16 | — | — | US | disclosed |
| US-6713482-B2 | SUCH AS (E)-1-(2-PYRIDYL)-2-STYRYL-1H-BENZIMIDAZOLE; ANTIINFLAMMATORY AND ANALGESIC AGENTS; PROSTAGLANDIN INHIBITORS | PFIZER INC. | 2004-03-30 | — | — | US | disclosed |
| US-20030013886-A1 | Benzimidazole cyclooxygenase-2 inhibitors | OKUMURA YOSHIYUKI (JP) | 2003-01-16 | — | — | US | disclosed |
| EP-0937722-B1 | Benzimidazole derivatives as cyclooxygenase-2 inhibitors | PFIZER (US) | 2002-07-03 | — | — | EP | disclosed |
| US-6310079-B1 | NON-STEROIDAL ANTIINFLAMMATORY AGENTS | PFIZER INC. | 2001-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030013886-A1 | Benzimidazole cyclooxygenase-2 inhibitors | PTGS1, CBR1, CBR3 | ALDH1A1 209/4885KDM4E 1257/4885RAB9A 4694/4885 |
| US-20040181062-A1 | Benzimidazole cyclooxygenase-2 inhibitor | PTGS1, CBR1, CBR3 | ALDH1A1 203/4885KDM4E 1153/4885RAB9A 4729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.