Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.47 |
| ▸ | FNTA | P49354 | 1/20 | 0.45 |
| ▸ | FNTB | P49356 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 3/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 4/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.38 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL344669 | 0.80 | PPARA (0.63) | KLK5KLK7PPARASYKACE | |
| SCHEMBL344670 | 0.80 | PPARA (0.63) | KLK5KLK7PPARASYKACE | |
| SCHEMBL84710 | 0.80 | PPARA (0.63) | KLK5KLK7PPARASYKACE | |
| SCHEMBL10564283 | 0.79 | SYK (0.54) | PPARASYKBACE1PPARG | |
| SCHEMBL31377096 | 0.79 | KLK5 (0.54) | KLK5KLK7PPARASYKACE | |
| SCHEMBL15850871 | 0.78 | MMP9 (0.53) | ACEBACE1MMP9SLC15A1 | |
| SCHEMBL15122765 | 0.77 | PPARA (0.49) | KLK5KLK7PPARASYKACE | |
| SCHEMBL28795441 | 0.77 | PPARA (0.49) | KLK5KLK7PPARASYKACE | |
| SCHEMBL28888891 | 0.77 | PPARA (0.49) | KLK5KLK7PPARASYKACE | |
| SCHEMBL30522106 | 0.77 | MMP9 (0.45) | KLK5KLK7PPARASYKACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6753409-B1 | FOR TREATMENT OF MYOCARDIAL INFARCTION, STROKE, PERIPHERAL ARTERIAL DISEASE AND DISSEMINATED INTRAVASCULAR COAGULATION | AVENTIS PHARMACEUTICALS INC. | 2004-06-22 | — | — | US | claimed |