Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Medronic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MMP2 | P08253 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | BLM | P54132 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | FDPS | P14324 | 3/20 | 0.48 |
| ▸ | OTC | P00480 | 1/20 | 0.48 |
| ▸ | GABBR2 | O75899 | 2/20 | 0.46 |
| ▸ | GABBR1 | Q9UBS5 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA3 | P07451 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Medronic Acid SCHEMBL4629922 | 1.00 | THRB (0.56) | THRBKDM4EMMP2MAPK1HSD17B10 | |
| Medronic Acid SCHEMBL6363918 | 1.00 | THRB (0.56) | THRBKDM4EMMP2MAPK1HSD17B10 | |
| Medronic Acid SCHEMBL220566 | 1.00 | THRB (0.56) | THRBKDM4EMMP2MAPK1HSD17B10 | |
| Medronic Acid SCHEMBL10982969 | 0.97 | THRB (0.59) | THRBKDM4EMMP2MAPK1HSD17B10 | |
| Medronic Acid SCHEMBL5159603 | 0.97 | THRB (0.59) | THRBKDM4EMMP2MAPK1HSD17B10 | |
| Medronic Acid SCHEMBL6664306 | 0.97 | THRB (0.59) | THRBKDM4EMMP2MAPK1HSD17B10 | |
| Medronic Acid SCHEMBL10985795 | 0.97 | THRB (0.59) | THRBKDM4EMMP2MAPK1HSD17B10 | |
| Diaminooctane SCHEMBL10974775 | 0.97 | THRB (0.59) | THRBKDM4EMMP2MAPK1HSD17B10 | |
| Medronic Acid SCHEMBL10976068 | 0.97 | THRB (0.59) | THRBKDM4EMMP2MAPK1HSD17B10 | |
| Medronic Acid SCHEMBL180702 | 0.97 | THRB (0.59) | THRBKDM4EMMP2MAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170273883-A1 | METHOD FOR TREATING AND COLORING HAIR COMPRISING UN-PIGMENTED HAIR | THE PROCTER & GAMBLE COMPANY | 2017-09-28 | — | — | US | disclosed |
| EP-3222267-A1 | METHOD FOR TREATING AND COLORING HAIR COMPRISING UN-PIGMENTED HAIR | The Procter and Gamble Company (US) | 2017-09-27 | — | — | EP | disclosed |
| US-6756353-B1 | CONTAINING HYDROPHOBICALLY MODIFIED CELLULOSIC MATERIAL OF SPECIFIC PARTICLE SIZE; IMPROVED APPEARANCE AND INTEGRITY OF LAUNDERED FABRICS AND TEXTILES | THE PROCTER & GAMBLE COMPANY | 2004-06-29 | — | — | US | disclosed |
| US-6599871-B2 | Comprising a nonionic surfactant having a melting point above ambient temperature and obtainable by heating and melting the nonionic surfactant, applying to a premix and forming; dustless; automatic dishwasher and laundry washers; hardness | THE PROCTER & GAMBLE COMPANY | 2003-07-29 | — | — | US | disclosed |
| US-20020082186-A1 | DETERGENT TABLET | PROCTER & GAMBLE COMPANY, THE | 2002-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170273883-A1 | METHOD FOR TREATING AND COLORING HAIR COMPRISING UN-PIGMENTED HAIR | PRKACG, PRKACB, MC1R | PDE3A 551/4885THRB 1121/4885KDM4E 1572/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.