Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER3 | P43115 | 8/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13120826 | 0.84 | ALDH1A1 (0.45) | PTGER3ALDH1A1KDM4ESMN1; SMN2HTT | |
| SCHEMBL3188133 | 0.83 | HTT (0.52) | ALDH1A1KDM4ESMN1; SMN2HTTLMNA | |
| SCHEMBL8474847 | 0.82 | PTGER3 (0.52) | PTGER3ALDH1A1KDM4ESMN1; SMN2HTT | |
| SCHEMBL13120885 | 0.80 | ALDH1A1 (0.37) | ALDH1A1KDM4ESMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL13120883 | 0.80 | ALDH1A1 (0.38) | ALDH1A1KDM4ESMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL8486843 | 0.80 | PTGER3 (0.44) | PTGER3ALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL14302460 | 0.78 | PTGER3 (0.52) | PTGER3ALDH1A1KDM4ESMN1; SMN2HTT | |
| SCHEMBL13120806 | 0.78 | LMNA (0.51) | PTGER3ALDH1A1KDM4ESMN1; SMN2HTT | |
| SCHEMBL13120787 | 0.76 | KMT2A (0.46) | PTGER3ALDH1A1HTTL3MBTL1LMNA | |
| SCHEMBL1770083 | 0.76 | EGLN1 (0.62) | PTGER3ALDH1A1KDM4ESMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| US-7812038-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2010-10-12 | — | — | US | disclosed |
| US-7812038-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2010-10-12 | — | — | US | disclosed |
| EP-1176956-B1 | CARBOXYLIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS | ENCYSIVE PHARMACEUTICALS INC (US) | 2008-01-09 | — | — | EP | disclosed |