Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1092493 | 0.84 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL6837380 | 0.77 | L3MBTL1 (0.49) | ALDH1A1POLBMAPTL3MBTL1ATM | |
| SCHEMBL14370503 | 0.77 | L3MBTL1 (0.51) | ALDH1A1POLBMAPTL3MBTL1ATM | |
| SCHEMBL26741264 | 0.76 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1KMT2AATMKDM4E | |
| SCHEMBL13034152 | 0.76 | SMN1; SMN2 (0.57) | ALDH1A1MAPTL3MBTL1KMT2AATM | |
| SCHEMBL687701 | 0.75 | L3MBTL1 (0.50) | ALDH1A1POLBMAPTL3MBTL1KMT2A | |
| SCHEMBL13034142 | 0.74 | L3MBTL1 (0.54) | ALDH1A1MAPTL3MBTL1KMT2AATM | |
| SCHEMBL30025953 | 0.74 | ALDH1A1 (0.42) | ALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL687293 | 0.74 | DPP4 (0.59) | ALDH1A1POLBMAPTL3MBTL1ATM | |
| SCHEMBL6837376 | 0.73 | ALDH1A1 (0.43) | ALDH1A1POLBMAPTL3MBTL1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| US-7812038-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2010-10-12 | — | — | US | disclosed |
| US-7812038-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2010-10-12 | — | — | US | disclosed |