Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22426270 | 0.95 | SMN1; SMN2 (0.59) | SMN1; SMN2KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL22426269 | 0.95 | SMN1; SMN2 (0.59) | SMN1; SMN2KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL22426232 | 0.92 | SMN1; SMN2 (0.64) | SMN1; SMN2KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL22426231 | 0.92 | SMN1; SMN2 (0.64) | SMN1; SMN2KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL22426241 | 0.85 | KMT2A (0.78) | SMN1; SMN2KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL22426242 | 0.85 | KMT2A (0.78) | SMN1; SMN2KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL6214766 | 0.85 | SMN1; SMN2 (0.66) | SMN1; SMN2KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL9634928 | 0.82 | SMN1; SMN2 (0.69) | SMN1; SMN2KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL22426264 | 0.82 | SMN1; SMN2 (0.69) | SMN1; SMN2KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL22426258 | 0.78 | ALDH1A1 (0.71) | SMN1; SMN2KMT2AMEN1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1203766-B1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC (US) | 2012-02-29 | — | — | EP | disclosed |
| US-7812038-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2010-10-12 | — | — | US | disclosed |
| US-7812038-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2010-10-12 | — | — | US | disclosed |
| EP-1176956-B1 | CARBOXYLIC ACID DERIVATIVES THAT INHIBIT THE BINDING OF INTEGRINS TO THEIR RECEPTORS | ENCYSIVE PHARMACEUTICALS INC (US) | 2008-01-09 | — | — | EP | disclosed |