Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.47 |
| ▸ | RAB9A | P51151 | 8/20 | 0.47 |
| ▸ | HPGD | P15428 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6837960 | 0.99 | ADRA2A (0.47) | NPC1RAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL6837776 | 0.90 | ERN1 (0.50) | NPC1RAB9AHPGDALDH1A1KDM4E | |
| SCHEMBL6837533 | 0.80 | PDE4A (0.49) | NPC1RAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL6836451 | 0.80 | ADRA2A (0.63) | NPC1RAB9AHPGDALDH1A1KDM4E | |
| SCHEMBL6838163 | 0.80 | ADRA2A (0.63) | NPC1RAB9AHPGDALDH1A1KDM4E | |
| SCHEMBL6836705 | 0.79 | ADRA2A (0.54) | NPC1RAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL7055204 | 0.79 | LMNA (0.48) | ALDH1A1KDM4EKMT2A | |
| SCHEMBL6833377 | 0.79 | ADRA2A (0.55) | NPC1RAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL6836417 | 0.78 | ADRA2A (0.46) | NPC1RAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL6837790 | 0.78 | ADRA2A (0.54) | NPC1RAB9AHPGDHSD17B10ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716987-B1 | PHOSPHODIESTERASE IV INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2004-04-06 | — | — | US | disclosed |
| US-6514996-B2 | Derivatives of benzofuran or benzodioxole | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2003-02-04 | — | — | US | disclosed |