Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 5/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.53 |
| ▸ | FAAH | O00519 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6837970 | 0.92 | ADRA2A (0.52) | ADRA2AADRA2BADRA2CFAAHMAPT | |
| SCHEMBL6838117 | 0.91 | ADRA2A (0.52) | ADRA2AADRA2BADRA2CMAPTKDM4E | |
| SCHEMBL6837901 | 0.91 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CFAAHMAPT | |
| SCHEMBL6836438 | 0.91 | F10 (0.55) | ADRA2AADRA2BADRA2CMAPTKDM4E | |
| SCHEMBL6837879 | 0.90 | ADRA2A (0.52) | ADRA2AADRA2BADRA2CFAAHKDM4E | |
| Hydrochloric Acid SCHEMBL6838058 | 0.90 | ALDH1A1 (0.52) | ADRA2AADRA2BADRA2CFAAHUSP2 | |
| SCHEMBL6836715 | 0.89 | ADRA2A (0.54) | ADRA2AADRA2BADRA2CMAPTKDM4E | |
| SCHEMBL6838073 | 0.85 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CMAPTKDM4E | |
| SCHEMBL6838071 | 0.85 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CMAPTKDM4E | |
| SCHEMBL6837782 | 0.83 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716987-B1 | PHOSPHODIESTERASE IV INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2004-04-06 | — | — | US | disclosed |
| US-6514996-B2 | Derivatives of benzofuran or benzodioxole | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2003-02-04 | — | — | US | disclosed |
| US-20020128290-A1 | DERIVATIVES OF BENZOFURAN OR BENZODIOXOLE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2002-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128290-A1 | DERIVATIVES OF BENZOFURAN OR BENZODIOXOLE | CBR1, CBR3, CYC1 | ADRA2A 1965/4885ADRA2B 1631/4885ADRA2C 1669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.