SCHEMBL6838675

SCHEMBL6838675

Fc1ccc2c(c1)nc(C(F)(F)F)c1nc(-c3ncc[nH]3)n(CCC3CNCCO3)c12

nearest known ligand 0.36

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 8/20 0.36
SLC6A4 P31645 7/20 0.36
SLC6A3 Q01959 3/20 0.36
EPHA2 P29317 3/20 0.35
SSTR4 P31391 1/20 0.32
KDR P35968 1/20 0.31
SYK P43405 1/20 0.31
MKNK1 Q9BUB5 1/20 0.31
GRIN1 Q05586 1/20 0.30
GRIN2B Q13224 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6838090 0.92 EPHA2 (0.34) SLC6A2SLC6A4EPHA2KDRSYK
SCHEMBL6840135 0.92 JAK1 (0.31) SLC6A2SLC6A4EPHA2SYK
SCHEMBL6837700 0.87 SLC6A2 (0.38) SLC6A2SLC6A4SLC6A3EPHA2SSTR4
SCHEMBL6838709 0.86 CCR3 (0.33) SLC6A4
SCHEMBL6837740 0.86 SLC6A2 (0.42) SLC6A2SLC6A4SLC6A3EPHA2SSTR4
SCHEMBL6838494 0.85 SLC6A2 (0.35) SLC6A2SLC6A4SLC6A3EPHA2SSTR4
SCHEMBL6838669 0.84 SSTR4 (0.37) SLC6A2SLC6A4SLC6A3SSTR4GRIN1
SCHEMBL6838620 0.83 SLC6A2 (0.38) SLC6A2SLC6A4SLC6A3EPHA2SSTR4
SCHEMBL6838725 0.83 SLC6A2 (0.37) SLC6A2SLC6A4SLC6A3EPHA2SSTR4
SCHEMBL6840144 0.82 SLC6A2 (0.37) SLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040054182-A1 1h-imidazopyridine derivatives HOKURIKU SEIYAKU CO., LTD. (JP) 2004-03-18 US disclosed
EP-1256582-A1 1H-IMIDAZOPYRIDINE DERIVATIVES HOKURIKU SEIYAKU CO., LTD. (JP) 2002-11-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040054182-A1 1h-imidazopyridine derivatives IL2, IL1A, IL4 SLC6A2 4336/4885SLC6A4 3973/4885SLC6A3 4270/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.