Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 3/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 7/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6846586 | 0.96 | RET (0.38) | RETPDGFRBERBB2IGF1RMEN1 | |
| SCHEMBL4992291 | 0.90 | KDR (0.44) | RETPDGFRBERBB2IGF1RMEN1 | |
| SCHEMBL4992299 | 0.90 | KDR (0.44) | RETPDGFRBERBB2IGF1RMEN1 | |
| SCHEMBL4987664 | 0.80 | MAOA (0.42) | RETPDGFRBERBB2IGF1RMEN1 | |
| SCHEMBL4987670 | 0.80 | MAOA (0.42) | RETPDGFRBERBB2IGF1RMEN1 | |
| SCHEMBL4995302 | 0.80 | SRC (0.47) | RETPDGFRBKDR | |
| SCHEMBL4995298 | 0.80 | SRC (0.47) | RETPDGFRBKDR | |
| SCHEMBL4996685 | 0.79 | DRD2 (0.38) | RETPDGFRBERBB2IGF1RKDR | |
| SCHEMBL4996688 | 0.79 | DRD2 (0.38) | RETPDGFRBERBB2IGF1RKDR | |
| SCHEMBL4993056 | 0.79 | SRC (0.46) | RETPDGFRBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6765012-B2 | FOR MODULATING TYROSINE KINASE SIGNAL TRANSDUCTION IN ORDER TO REGULATE, MODULATE AND/OR INHIBIT ABNORMAL CELL PROLIFERATION | ALLERGAN, INC. | 2004-07-20 | — | — | US | claimed |