Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 11/20 | 0.48 |
| ▸ | BRD4 | O60885 | 3/20 | 0.48 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 3/20 | 0.40 |
| ▸ | TTK | P33981 | 5/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.37 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.37 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7743634 | 0.91 | PLK1 (0.46) | PLK1BRD4BRDTALKRAD52 | |
| SCHEMBL6844374 | 0.84 | PLK1 (0.44) | PLK1BRD4BRDTALKRAD52 | |
| SCHEMBL6840386 | 0.83 | STK4 (0.34) | PLK1BRD4BRDT | |
| SCHEMBL2026861 | 0.81 | PLK1 (0.54) | PLK1BRD4BRDTALKTTK | |
| SCHEMBL2026862 | 0.81 | PLK1 (0.54) | PLK1BRD4BRDTALKTTK | |
| SCHEMBL6840399 | 0.81 | PLK1 (0.42) | PLK1BRD4BRDTALKRAD52 | |
| SCHEMBL6844484 | 0.79 | PLK1 (0.39) | PLK1BRD4BRDTALKRAD52 | |
| SCHEMBL2032053 | 0.74 | PLK1 (0.50) | PLK1BRD4BRDTPLK3 | |
| SCHEMBL2026907 | 0.74 | PLK1 (0.50) | PLK1BRD4BRDTPLK3 | |
| SCHEMBL6840522 | 0.73 | USP1 (0.35) | PRKDCPIK3CDPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516441-B1 | PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE | ELAN PHARM INC (US) | 2015-01-21 | — | — | EP | disclosed |
| WO-2011079118-A1 | PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC (US) | 2011-06-30 | — | — | WO | disclosed |