Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 2/20 | 0.35 |
| ▸ | STK4 | Q13043 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | GSK3B | P49841 | 3/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | MYC | P01106 | 1/20 | 0.30 |
| ▸ | PRKDC | P78527 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6840386 | 0.91 | STK4 (0.34) | STK4RPS6KA3ATRMAPTGSK3B | |
| SCHEMBL6844424 | 0.84 | CYP11B2 (0.35) | USP1STK4RPS6KA3 | |
| SCHEMBL7743634 | 0.82 | PLK1 (0.46) | PIK3CDPIK3CAPIK3CGPRKDC | |
| SCHEMBL6840403 | 0.82 | STK4 (0.38) | USP1STK4RPS6KA3TGFBR1 | |
| SCHEMBL6844422 | 0.79 | STK4 (0.36) | USP1STK4RPS6KA3 | |
| SCHEMBL7742264 | 0.79 | KCNA5 (0.34) | STK4RPS6KA3 | |
| SCHEMBL2030617 | 0.78 | PLK1 (0.53) | STK4 | |
| SCHEMBL6840300 | 0.73 | PLK1 (0.48) | PIK3CDPIK3CAPIK3CGPRKDC | |
| SCHEMBL2031221 | 0.72 | BRD4 (0.53) | RPS6KA3 | |
| SCHEMBL2031223 | 0.72 | BRD4 (0.53) | RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079118-A1 | PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC (US) | 2011-06-30 | — | — | WO | disclosed |