Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 15/20 | 0.34 |
| ▸ | PLK2 | Q9NYY3 | 14/20 | 0.34 |
| ▸ | PLK3 | Q9H4B4 | 12/20 | 0.34 |
| ▸ | BRD4 | O60885 | 4/20 | 0.34 |
| ▸ | TAF1 | P21675 | 2/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | PRKCG | P05129 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.32 |
| ▸ | NEK4 | P51957 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.32 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.32 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.32 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.32 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.32 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18475419 | 0.69 | PLK1 (0.38) | PLK1PLK2PLK3BRD4TAF1 | |
| SCHEMBL18476409 | 0.69 | PLK1 (0.38) | PLK1PLK2PLK3BRD4TAF1 | |
| SCHEMBL7750944 | 0.69 | PLK1 (0.37) | PLK1PLK2PLK3BRD4TAF1 | |
| SCHEMBL14193656 | 0.67 | PLK1 (0.37) | PLK1PLK2PLK3BRD4TAF1 | |
| SCHEMBL16984420 | 0.65 | PLK1 (0.37) | PLK1PLK2PLK3BRD4TAF1 | |
| SCHEMBL10144547 | 0.64 | PLK1 (0.39) | PLK1PLK2PLK3BRD4 | |
| SCHEMBL23428556 | 0.61 | HSD11B1 (0.30) | — | |
| SCHEMBL16416806 | 0.60 | PLK1 (0.49) | PLK1PLK2PLK3BRD4 | |
| SCHEMBL16416798 | 0.60 | PLK1 (0.49) | PLK1PLK2PLK3BRD4 | |
| SCHEMBL16984421 | 0.58 | PLK1 (0.54) | PLK1PLK2PLK3BRD4TAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079118-A1 | PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC (US) | 2011-06-30 | — | — | WO | disclosed |