Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR3 | P32745 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5254842 | 1.00 | SSTR3 (0.47) | SSTR3SCN9AALDH1A1MEN1KMT2A | |
| SCHEMBL5257922 | 1.00 | SSTR3 (0.47) | SSTR3SCN9AALDH1A1MEN1KMT2A | |
| SCHEMBL6839364 | 0.87 | SMN1; SMN2 (0.41) | RAB9ASMN1; SMN2MAPTKDM4ENPC1 | |
| SCHEMBL5256198 | 0.87 | SMN1; SMN2 (0.41) | RAB9ASMN1; SMN2MAPTKDM4ENPC1 | |
| SCHEMBL5258116 | 0.83 | SSTR3 (0.49) | SSTR3 | |
| SCHEMBL5340986 | 0.82 | SSTR3 (0.46) | SSTR3SCN9AALDH1A1MEN1KMT2A | |
| SCHEMBL5340990 | 0.82 | SSTR3 (0.46) | SSTR3SCN9AALDH1A1MEN1KMT2A | |
| SCHEMBL5257713 | 0.82 | HPGDS (0.46) | PDE3BPDE3A | |
| SCHEMBL6838493 | 0.82 | HPGDS (0.46) | PDE3BPDE3A | |
| SCHEMBL5255112 | 0.81 | SSTR3 (0.52) | SSTR3SCN9AALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6759428-B2 | SUCH AS N-((1,2)-2-(((CYANO(CYCLOPROPYL)METHYL)AMINO)CARBONYL) CYCLOHEXYL)-1H-INDOLE-2-CARBOXAMIDE; CATHEPSIN K INHIBITORS | ROCHE PALO ALTO LLC | 2004-07-06 | — | — | US | disclosed |