Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMBR | P28336 | 3/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.62 |
| ▸ | TACR1 | P25103 | 2/20 | 0.60 |
| ▸ | CASP1 | P29466 | 1/20 | 0.59 |
| ▸ | MMP2 | P08253 | 3/20 | 0.59 |
| ▸ | MMP9 | P14780 | 3/20 | 0.59 |
| ▸ | MMP8 | P22894 | 3/20 | 0.59 |
| ▸ | MMP14 | P50281 | 3/20 | 0.59 |
| ▸ | BMP1 | P13497 | 1/20 | 0.58 |
| ▸ | APAF1 | O14727 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12203727 | 1.00 | NMBR (0.70) | NMBRKDM4EALDH1A1MAPK1MAPT | |
| SCHEMBL19015787 | 0.91 | NMBR (0.68) | NMBRKDM4EALDH1A1MAPK1MAPT | |
| SCHEMBL1318661 | 0.87 | NMBR (0.73) | NMBRMAPTGAAHTTLMNA | |
| SCHEMBL13073927 | 0.87 | NMBR (0.64) | NMBRKDM4EMAPTGAAHTT | |
| SCHEMBL17319524 | 0.87 | NMBR (0.73) | NMBRMAPTGAAHTTLMNA | |
| SCHEMBL29401413 | 0.87 | NMBR (0.73) | NMBRMAPTGAAHTTLMNA | |
| SCHEMBL1285921 | 0.87 | NMBR (0.76) | NMBRMAPTGAAHTTLMNA | |
| SCHEMBL29935468 | 0.87 | NMBR (0.76) | NMBRMAPTGAAHTTLMNA | |
| SCHEMBL3808330 | 0.87 | NMBR (0.76) | NMBRMAPTGAAHTTLMNA | |
| SCHEMBL3265534 | 0.87 | NMBR (0.76) | NMBRMAPTGAAHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130023463-A1 | HIV PROTEASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 2013-01-24 | — | — | US | disclosed |
| US-8193227-B2 | HIV protease inhibiting compounds | ABBOTT LABORATORIES (US) | 2012-06-05 | — | — | US | disclosed |
| US-20110003827-A1 | HIV protease inhibiting compounds | ABBVIE INC. | 2011-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003827-A1 | HIV protease inhibiting compounds | SERPINB1, HPN, DNPEP | NMBR 4207/4885KDM4E 3048/4885ALDH1A1 2920/4885 |
| US-20130023463-A1 | HIV PROTEASE INHIBITING COMPOUNDS | SERPINB1, HPN, DNPEP | NMBR 4207/4885KDM4E 3048/4885ALDH1A1 2920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.