⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28886 | 0.81 | APP (0.35) | — | |
| Hydrochloric Acid SCHEMBL9124177 | 0.78 | CYP3A4 (0.33) | — | |
| SCHEMBL1070719 | 0.76 | MAPT (0.35) | — | |
| SCHEMBL2811331 | 0.75 | — | — | |
| SCHEMBL17447241 | 0.75 | APP (0.46) | — | |
| SCHEMBL178623 | 0.75 | — | — | |
| SCHEMBL29728987 | 0.75 | — | — | |
| SCHEMBL2812022 | 0.71 | CYP1A1 (0.41) | — | |
| SCHEMBL63173 | 0.71 | — | — | |
| SCHEMBL514947 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6762281-B2 | GENERATING PREFERENTIAL OLIGOMERS; GENERATE OLIGOMER, DEPROTECT, EXPOSE TO PHOSPHOROUS, OXIDIZE, EXPOSE TO SULFUR, CLEAVE, RECOVER PRODUCT | ISIS PHARMACEUTICALS, INC. | 2004-07-13 | — | — | US | disclosed |
| US-20040019000-A1 | Polyalkyleneamine-containing oligomers | ISIS PHARMACEUTICALS, INC. | 2004-01-29 | — | — | US | disclosed |
| US-20020156235-A1 | Process for preparing peptide derivatized oligomeric compounds | IONIS PHARMACEUTICALS, INC. | 2002-10-24 | — | — | US | disclosed |
| WO-2002020544-A1 | PROCESS FOR PREPARING PEPTIDE DERIVATIZED OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS, INC. (US) | 2002-03-14 | — | — | WO | disclosed |