Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 2/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.65 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.65 |
| ▸ | HINT1 | P49773 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.63 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.62 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.62 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9153707 | 0.90 | NT5E (0.64) | NT5EADORA3ADORA2AHINT1LMNA | |
| SCHEMBL972927 | 0.89 | LMNA (0.78) | NT5EADORA3ADORA2ALMNAHIF1A | |
| SCHEMBL16579288 | 0.89 | LMNA (0.78) | NT5EADORA3ADORA2ALMNAHIF1A | |
| SCHEMBL10176676 | 0.89 | LMNA (0.78) | NT5EADORA3ADORA2ALMNAHIF1A | |
| SCHEMBL20419174 | 0.89 | LMNA (0.78) | NT5EADORA3ADORA2ALMNAHIF1A | |
| SCHEMBL24359132 | 0.89 | LMNA (0.78) | NT5EADORA3ADORA2ALMNAHIF1A | |
| SCHEMBL10159432 | 0.89 | LMNA (0.78) | NT5EADORA3ADORA2ALMNAHIF1A | |
| SCHEMBL3741590 | 0.89 | LMNA (0.78) | NT5EADORA3ADORA2ALMNAHIF1A | |
| SCHEMBL22559823 | 0.89 | LMNA (0.78) | NT5EADORA3ADORA2ALMNAHIF1A | |
| SCHEMBL114918 | 0.89 | LMNA (0.78) | NT5EADORA3ADORA2ALMNAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756496-B1 | SUCH AS TRIETHYLAMMONIUM-5'-DIMETHOXYTRITYL-3'-THYMIDINE-HYDROGEN PHOSPHONONDITHIOATE FOR USE AS ANTIVIRAL AND ANTICANCER AGENTS | ISIS PHARMACEUTICALS, INC. | 2004-06-29 | — | — | US | claimed |
| US-5565555-A | Nucleoside hydrogen phosphonodithioate diesters and activated phosphonodithioate analogues | GILEAD SCIENCES, INC. (US) | 1996-10-15 | — | — | US | claimed |
| US-5194599-A | Forming linkages with nuclosides and nucleotides; viricides, anticarcinogenic agents | GILEAD SCIENCES, INC. (US) | 1993-03-16 | — | — | US | claimed |
| EP-0360609-A2 | Novel hydrogen phosphonodithioate compositions | GILEAD SCIENCES, INC. (US) | 1990-03-28 | — | — | EP | claimed |