Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.78 |
| ▸ | NT5E | P21589 | 1/20 | 0.78 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.78 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.77 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.77 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.75 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.73 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.73 |
| ▸ | DPP4 | P27487 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.72 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.72 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.72 |
| ▸ | GAPDH | P04406 | 1/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.72 |
| ▸ | STAT6 | P42226 | 1/20 | 0.72 |
| ▸ | PI4KA | P42356 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16579288 | 1.00 | LMNA (0.78) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL10176676 | 1.00 | LMNA (0.78) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL20419174 | 1.00 | LMNA (0.78) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL7168927 | 1.00 | LMNA (0.78) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL10159432 | 1.00 | LMNA (0.78) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL24359132 | 1.00 | LMNA (0.78) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL972927 | 1.00 | LMNA (0.78) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL114918 | 1.00 | LMNA (0.78) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL22559823 | 1.00 | LMNA (0.78) | LMNANT5EHIF1AADORA2AADORA3 | |
| SCHEMBL440329 | 1.00 | LMNA (0.78) | LMNANT5EHIF1AADORA2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7838508-B2 | 4′-thio-L-xyloy furanosyl nucleosides, precursors thereof, preparation and use thereof | SOUTHERN RESEARCH INSTITUTE (US) | 2010-11-23 | — | — | US | disclosed |
| US-20070112004-A1 | 4'-THIO-L-XYLOY FURANOSYL NUCLEOSIDES, PRECURSORS THEREOF, PREPARATION AND USE THEREOF | SOUTHERN RESEARCH INSTITUTE (US) | 2007-05-17 | — | — | US | disclosed |
| US-6914061-B2 | 4′-thio-L-xylofuranosyl nucleosides, precursors thereof, preparation and use thereof | SOUTHERN RESEARCH INSTITUTE (US) | 2005-07-05 | — | — | US | disclosed |
| US-6699979-B2 | PREPARED VIA A STEREOSPECIFIC SN2 NUCLEOPHILIC ATTACK OF A PHOSPHODIESTER, OR PHOSPHOROTHIOATE, ON THE 3' POSITION OF A XYLONUCLEOTIDE; USEFUL IN ANTISENSE OR PROBE TECHNOLOGY | ISIS PHARMACEUTICALS, INC. | 2004-03-02 | — | — | US | disclosed |
| US-20030144235-A1 | Anticarcinogenic agents for treating cancer, a viricides for viral diseases, inhibit DNA replication | SOUTHERN RESEARCH INSTITUTE | 2003-07-31 | — | — | US | disclosed |
| US-6500945-B2 | BIOSYNTHESIS; STEREOSPECIFIC | ISIS PHARMACEUTICALS, INC. | 2002-12-31 | — | — | US | disclosed |
| US-20020137921-A1 | Oligonucleotides having chiral phosphorus linkages | COOK PHILLIP DAN (US) | 2002-09-26 | — | — | US | disclosed |
| EP-0655088-B1 | OLIGONUCLEOTIDES HAVING CHIRAL PHOSPHORUS LINKAGES | ISIS PHARMACEUTICALS INC (US) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001066118-A1 | 4'-THIO-L-XYLO FURANOSYL NUCLEOSIDES, PRECURSORS THEREOF, PREPARATION AND USE THEREOF | SOUTHERN RESEARCH INSTITUTE (US) | 2001-09-13 | — | — | WO | disclosed |
| US-20010008936-A1 | Oligonucleotides having chiral phosphorus linkages | ISIS PHARMACEUTICALS, INC. | 2001-07-19 | — | — | US | disclosed |
| US-6239265-B1 | FOR RESEARCH AND DIAGNOSIS | ISIS PHARMACEUTICALS, INC. | 2001-05-29 | — | — | US | disclosed |
| US-5852188-A | Oligonucleotides having chiral phosphorus linkages | ISIS PHARMACEUTICALS, INC. (US) | 1998-12-22 | — | — | US | disclosed |
| US-5521302-A | NUCLEOPHILIC REACTION OF PHOSPHATE GROUPS | ISIS PHARMACEUTICALS, INC. (US) | 1996-05-28 | — | — | US | disclosed |
| US-5212295-A | Monomers for preparation of oligonucleotides having chiral phosphorus linkages | ISIS PHARMACEUTICALS (US) | 1993-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144235-A1 | Anticarcinogenic agents for treating cancer, a viricides for viral diseases, inhibit DNA replication | POLL, PCNA, YWHAZ | LMNA 1080/4885NT5E 992/4885HIF1A 1026/4885 |
| US-20020137921-A1 | Oligonucleotides having chiral phosphorus linkages | RNGTT, PNP, PSPH | LMNA 3960/4885NT5E 434/4885HIF1A 4777/4885 |
| US-20070112004-A1 | 4'-THIO-L-XYLOY FURANOSYL NUCLEOSIDES, PRECURSORS THEREOF, PREPARATION AND USE THEREOF | POLL, PNP, UNG | LMNA 741/4885NT5E 186/4885HIF1A 1775/4885 |
| US-20010008936-A1 | Oligonucleotides having chiral phosphorus linkages | RNGTT, PNP, PSPH | LMNA 3960/4885NT5E 434/4885HIF1A 4777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.