Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.66 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.66 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.66 |
| ▸ | MRGPRX4 | Q96LA9 | 8/20 | 0.60 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.58 |
| ▸ | RELA | Q04206 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2650306 | 0.96 | MEN1 (0.69) | MEN1KMT2ANR4A2NR4A1NR4A3 | |
| SCHEMBL8058838 | 0.89 | MEN1 (0.59) | MEN1KMT2ANR4A2NR4A1NR4A3 | |
| SCHEMBL6840895 | 0.87 | MRGPRX4 (0.57) | MEN1KMT2ANR4A2NR4A1NR4A3 | |
| SCHEMBL28767935 | 0.86 | MEN1 (0.70) | MEN1KMT2ANR4A2NR4A1NR4A3 | |
| SCHEMBL4138759 | 0.86 | NR4A2 (0.81) | NR4A2MRGPRX4PKMRAB9ATP53 | |
| SCHEMBL862870 | 0.85 | MEN1 (0.93) | MEN1KMT2ANR4A2NR4A1NR4A3 | |
| SCHEMBL1750167 | 0.83 | NR4A2 (0.86) | MEN1KMT2ANR4A2NR4A1NR4A3 | |
| SCHEMBL6840892 | 0.83 | LMNA (0.61) | MEN1KMT2AMRGPRX4PKMRAB9A | |
| SCHEMBL8044554 | 0.82 | MEN1 (0.70) | MEN1KMT2ANR4A2NR4A1NR4A3 | |
| SCHEMBL16320242 | 0.82 | NR4A2 (0.71) | MEN1KMT2ANR4A2NR4A1NR4A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040157919-A1 | Trisubstituted carbocyclic cyclophilin binding compounds and their use | WU YONG-QIAN (US) | 2004-08-12 | — | — | US | disclosed |
| US-6656971-B2 | Non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilins; inhibiting their peptidyl-prolyl isomerase activity; treating variety of medical conditions | GUILFORD PHARMACEUTICALS INC. | 2003-12-02 | — | — | US | disclosed |
| EP-1360173-A2 | TRISUBSTITUTED CARBOCYCLIC CYCLOPHILIN BINDING COMPOUNDS AND THEIR USE | GUILFORD PHARMACEUTICALS INC. (US) | 2003-11-12 | — | — | EP | disclosed |
| US-20020165275-A1 | Trisubstituted carbocyclic cyclophilin binding compounds and their use | GUILFORD PHARMACEUTICALS INC. | 2002-11-07 | — | — | US | disclosed |
| WO-2002059080-A2 | TRISUBSTITUTED CARBOCYCLIC CYCLOPHILIN BINDING COMPOUNDS AND THEIR USE | GUILFORD PHARMACEUTICALS INC. (US) | 2002-08-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040157919-A1 | Trisubstituted carbocyclic cyclophilin binding compounds and their use | FKBP2, PPIG, FKBP8 | MEN1 4867/4885KMT2A 4618/4885NR4A2 1809/4885 |
| US-20020165275-A1 | Trisubstituted carbocyclic cyclophilin binding compounds and their use | FKBP2, PPIG, FKBP8 | MEN1 4867/4885KMT2A 4618/4885NR4A2 1809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.