Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6335926 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2KDM4EKMT2AMEN1L3MBTL1 | |
| SCHEMBL362333 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2KDM4EKMT2AMEN1L3MBTL1 | |
| SCHEMBL29652034 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2KDM4EKMT2AMEN1L3MBTL1 | |
| SCHEMBL6337655 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2KDM4EKMT2AMEN1L3MBTL1 | |
| SCHEMBL9120461 | 0.86 | SMN1; SMN2 (0.46) | SMN1; SMN2KDM4EKMT2AMEN1L3MBTL1 | |
| SCHEMBL158053 | 0.83 | SMN1; SMN2 (0.67) | SMN1; SMN2KDM4EKMT2AMEN1L3MBTL1 | |
| SCHEMBL306514 | 0.83 | SMN1; SMN2 (0.67) | SMN1; SMN2KDM4EKMT2AMEN1L3MBTL1 | |
| SCHEMBL1603596 | 0.83 | SMN1; SMN2 (0.67) | SMN1; SMN2KDM4EKMT2AMEN1L3MBTL1 | |
| SCHEMBL416659 | 0.83 | SMN1; SMN2 (0.67) | SMN1; SMN2KDM4EKMT2AMEN1L3MBTL1 | |
| SCHEMBL28535921 | 0.79 | KMT2A (0.43) | SMN1; SMN2KDM4EKMT2AMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6774263-B1 | N-(2-CHLORO-5-METHYLTHIOPHENYL)-N'-(3-METHYLSULFINYLPHENYL)-N' -METHYLGUANIDINE; NEURODEGENERATIVE DISORDER TREATMENT | CAMBRIDGE NEUROSCIENCE, INC. | 2004-08-10 | — | — | US | disclosed |
| EP-1041986-A4 | PHARMACEUTICALLY ACTIVE COMPOUND AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE INC (US) | 2001-03-21 | — | — | EP | disclosed |
| EP-1041986-A1 | PHARMACEUTICALLY ACTIVE COMPOUND AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE, INC. (US) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999018962-A1 | PHARMACEUTICALLY ACTIVE COMPOUND AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1999-04-22 | — | — | WO | disclosed |