Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | F2 | P00734 | 2/20 | 0.55 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.55 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.55 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL416659 | 1.00 | SMN1; SMN2 (0.67) | SMN1; SMN2KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL306514 | 1.00 | SMN1; SMN2 (0.67) | SMN1; SMN2KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL158053 | 1.00 | SMN1; SMN2 (0.67) | SMN1; SMN2KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL29652034 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL362333 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL6337655 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL6335926 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL6842010 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL29040265 | 0.83 | SMN1; SMN2 (0.82) | SMN1; SMN2KMT2AMEN1KDM4EL3MBTL1 | |
| SCHEMBL11623286 | 0.83 | SMN1; SMN2 (0.82) | SMN1; SMN2KMT2AMEN1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766360-B1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | BOEHRINGER INGELHEIM INT (DE) | 2017-07-12 | — | — | EP | disclosed |
| US-8815857-B2 | Soluble guanylate cyclase activators | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-08-26 | — | — | US | disclosed |
| US-8815857-B2 | Soluble guanylate cyclase activators | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-08-26 | — | — | US | disclosed |
| US-8716494-B2 | Pyrrolidinone carboxamide derivatives | CHEMOCENTRYX, INC. (US) | 2014-05-06 | — | — | US | disclosed |
| US-20130237514-A1 | PYRROLIDINONE CARBOXAMIDE DERIVATIVES | CHEMOCENTRYX, INC. (US) | 2013-09-12 | — | — | US | disclosed |
| US-20130203729-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-08-08 | — | — | US | disclosed |
| US-20130203729-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-08-08 | — | — | US | disclosed |
| US-8293925-B2 | Pyrrolidinone carboxamide derivatives | CHEMOCENTRYX, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| US-20110082172-A1 | PYRROLIDINONE CARBOXAMIDE DERIVATIVES | CHEMOCENTRYX, INC. (US) | 2011-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130203729-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | GUCY1A2, GUCY1A1, GUCY1B1 | SMN1; SMN2 626/4885KMT2A 4489/4885MEN1 905/4885 |
| US-20110082172-A1 | PYRROLIDINONE CARBOXAMIDE DERIVATIVES | CMKLR2, CMKLR1, GPR3 | SMN1; SMN2 4402/4885KMT2A 1682/4885MEN1 2606/4885 |
| US-20130237514-A1 | PYRROLIDINONE CARBOXAMIDE DERIVATIVES | CMKLR2, CMKLR1, GPR3 | SMN1; SMN2 4402/4885KMT2A 1682/4885MEN1 2606/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.