Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 2/20 | 0.48 |
| ▸ | MME | P08473 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25214759 | 0.82 | MMP8 (0.63) | MMP8CA1CA2KMT2AMAPT | |
| SCHEMBL25214750 | 0.82 | MMP8 (0.63) | MMP8CA1CA2KMT2AMAPT | |
| SCHEMBL25240460 | 0.82 | MMP8 (0.63) | MMP8CA1CA2KMT2AMAPT | |
| SCHEMBL20152030 | 0.81 | CA1 (0.57) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL24347008 | 0.81 | MMP8 (0.63) | MMP8CA1CA2KMT2AMAPT | |
| SCHEMBL24347010 | 0.81 | MMP8 (0.63) | MMP8CA1CA2KMT2AMAPT | |
| SCHEMBL6814514 | 0.80 | CA12 (0.64) | MMP8CA1CA2KMT2AMAPT | |
| SCHEMBL6813286 | 0.80 | CA12 (0.64) | MMP8CA1CA2KMT2AMAPT | |
| SCHEMBL993570 | 0.80 | CA12 (0.64) | MMP8CA1CA2KMT2AMAPT | |
| SCHEMBL19152432 | 0.80 | MAPT (0.72) | MMP8KMT2AMAPTL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040176463-A1 | Immediate release formulation of n-(2-propylpentanoyl)glycinamide | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-09-09 | — | — | US | claimed |
| WO-2004071424-A2 | IMMEDIATE RELEASE FORMULATION OF N-(2-PROPYLPENTANOYL)GLYCINAMIDE | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2004-08-26 | — | — | WO | claimed |
| EP-0659174-B1 | DERIVATIVES OF VALPROIC AND 2-VALPROENOIC ACID AMIDES AND USE AS ANTICONVULSANTS | YISSUM RES DEV CO (IL) | 1999-02-10 | — | — | EP | claimed |
| US-5585358-A | ANTIEPILEPTIC AGENTS; COGNITION ACTIVATORS; NERVOUS SYSTEM DISORDERS; DYSKINESIA; ANTIISCHEMIC AGENTS | YISSUM RESEARCH DEVELOPMENT CORPORATION OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1996-12-17 | — | — | US | claimed |
| EP-0659174-A4 | DERIVATIVES OF VALPROIC AND 2-VALPROENOIC ACID AMIDES AND USE AS ANTICONVULSANTS. | YISSUM RES DEV CO (IL) | 1995-09-27 | — | — | EP | claimed |
| EP-0659174-A1 | DERIVATIVES OF VALPROIC AND 2-VALPROENOIC ACID AMIDES AND USE AS ANTICONVULSANTS | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1995-06-28 | — | — | EP | claimed |
| WO-1995001956-A1 | DERIVATIVES OF VALPROIC AND 2-VALPROENOIC ACID AMIDES AND USE AS ANTICONVULSANTS | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1995-01-19 | — | — | WO | claimed |
| US-20040175423-A1 | Sustained release formulation of N- (2-propylpentanoyl) glycinamide and related compounds | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-09-09 | — | — | US | disclosed |
| US-20040176463-A1 | Immediate release formulation of n-(2-propylpentanoyl)glycinamide | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-09-09 | — | — | US | disclosed |
| EP-0659174-B1 | DERIVATIVES OF VALPROIC AND 2-VALPROENOIC ACID AMIDES AND USE AS ANTICONVULSANTS | YISSUM RES DEV CO (IL) | 1999-02-10 | — | — | EP | disclosed |
| US-5585358-A | ANTIEPILEPTIC AGENTS; COGNITION ACTIVATORS; NERVOUS SYSTEM DISORDERS; DYSKINESIA; ANTIISCHEMIC AGENTS | YISSUM RESEARCH DEVELOPMENT CORPORATION OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1996-12-17 | — | — | US | disclosed |
| EP-0659174-A4 | DERIVATIVES OF VALPROIC AND 2-VALPROENOIC ACID AMIDES AND USE AS ANTICONVULSANTS. | YISSUM RES DEV CO (IL) | 1995-09-27 | — | — | EP | disclosed |
| EP-0659174-A1 | DERIVATIVES OF VALPROIC AND 2-VALPROENOIC ACID AMIDES AND USE AS ANTICONVULSANTS | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1995-06-28 | — | — | EP | disclosed |
| WO-1995001956-A1 | DERIVATIVES OF VALPROIC AND 2-VALPROENOIC ACID AMIDES AND USE AS ANTICONVULSANTS | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1995-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176463-A1 | Immediate release formulation of n-(2-propylpentanoyl)glycinamide | CACNA1E, GRIK1, GRIN2D | MMP8 2148/4885HDAC3 25/4885HDAC4 255/4885 |
| US-20040175423-A1 | Sustained release formulation of N- (2-propylpentanoyl) glycinamide and related compounds | CACNA1E, GRIN2C, GRIN2D | MMP8 3113/4885HDAC3 46/4885HDAC4 242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.