Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.77 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.77 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.77 |
| ▸ | HPGD | P15428 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 1/20 | 0.70 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.69 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.66 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.66 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.66 |
| ▸ | PRKCG | P05129 | 1/20 | 0.66 |
| ▸ | PRKACA | P17612 | 1/20 | 0.66 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | AKT1 | P31749 | 1/20 | 0.66 |
| ▸ | GSK3A | P49840 | 1/20 | 0.66 |
| ▸ | GSK3B | P49841 | 1/20 | 0.66 |
| ▸ | PRKX | P51817 | 1/20 | 0.66 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.66 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11900090 | 0.94 | HDAC6 (0.85) | HDAC6HDAC2HDAC8HPGDLMNA | |
| SCHEMBL457082 | 0.90 | HDAC6 (0.79) | HDAC6HDAC2HDAC8HPGDLMNA | |
| SCHEMBL4747957 | 0.89 | NR1H4 (0.81) | HDAC6HDAC2HDAC8HPGDLMNA | |
| SCHEMBL29184442 | 0.88 | HDAC6 (0.76) | HDAC6HDAC2HDAC8HPGDLMNA | |
| Hydrochloric Acid SCHEMBL3757721 | 0.88 | HDAC6 (0.76) | HDAC6HDAC2HDAC8HPGDLMNA | |
| SCHEMBL6570908 | 0.87 | HDAC6 (1.00) | HDAC6HDAC2HDAC8HPGDLMNA | |
| SCHEMBL2924662 | 0.87 | HDAC6 (0.74) | HDAC6HDAC2HDAC8HPGDLMNA | |
| SCHEMBL539059 | 0.87 | EPHX2 (0.84) | HDAC6HDAC2HDAC8HPGDLMNA | |
| SCHEMBL6140514 | 0.85 | HDAC6 (0.72) | HDAC6HDAC2HDAC8HPGDLMNA | |
| SCHEMBL5604611 | 0.85 | HDAC6 (0.72) | HDAC6HDAC2HDAC8HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040063785-A1 | Symmetrically disubstituted aromatic compounds and pharmaceutical compositions for inhibiting poly (ADP-ribose) glycohydrolase, and methods for their use | GUILFORD PHARMACEUTICALS, INC. | 2004-04-01 | — | — | US | disclosed |
| EP-1360167-A1 | SYMMETRICALLY DISUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING POLY (ADP-RIBOSE) GLYCOHYDROLASE, AND METHODS FOR THEIR USE | GUILFORD PHARMACEUTICALS INC. (US) | 2003-11-12 | — | — | EP | disclosed |
| US-6635786-B2 | Symmetrically disubstituted aromatic compounds and pharmaceutical compositions for inhibiting poly (ADP-ribose) glycohydrolase, and methods for their use | GUILFORD PHARMACEUTICALS, INC. | 2003-10-21 | — | — | US | disclosed |
| US-20020132852-A1 | Symmetrically disubstituted aromatic compounds and pharmaceutical compositions for inhibiting poly (ADP-ribose) glycohydrolase, and methods for their use | GUILFORD PHARMACEUTICALS, INC. | 2002-09-19 | — | — | US | disclosed |
| WO-2002057211-A1 | SYMMETRICALLY DISUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING POLY (ADP-RIBOSE) GLYCOHYDROLASE, AND METHODS FOR THEIR USE | GUILFORD PHARMACEUTICALS, INC. (US) | 2002-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063785-A1 | Symmetrically disubstituted aromatic compounds and pharmaceutical compositions for inhibiting poly (ADP-ribose) glycohydrolase, and methods for their use | PARG, PARP1, PARP11 | HDAC6 499/4885HDAC2 712/4885HDAC8 895/4885 |
| US-20020132852-A1 | Symmetrically disubstituted aromatic compounds and pharmaceutical compositions for inhibiting poly (ADP-ribose) glycohydrolase, and methods for their use | PARG, PARP1, PARP11 | HDAC6 499/4885HDAC2 712/4885HDAC8 895/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.