Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 6/20 | 0.40 |
| ▸ | HTR3A | P46098 | 3/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL844863 | 0.77 | KMO (0.54) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL30110620 | 0.75 | LCK (0.44) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL844237 | 0.75 | LCK (0.48) | CHRNA7HTR3ANTRK1HTR1B | |
| SCHEMBL5704712 | 0.68 | CHRNA7 (0.84) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL6009103 | 0.68 | CHRNA7 (0.84) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL842944 | 0.67 | CHRNA7 (0.76) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| Hydrochloric Acid SCHEMBL6008706 | 0.67 | CHRNA7 (0.82) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL843041 | 0.67 | CHRNA7 (0.47) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL843871 | 0.67 | CHRNA7 (0.75) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL14608864 | 0.67 | CHRNA7 (0.49) | CHRNA7HTR3AHTR3EHTR3BHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406901-A1 | QUINUCLIDINES-SUBSTITUTED-MULTI-CYCLIC-HETEROARYLS FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-04-14 | — | — | EP | disclosed |
| WO-2002100857-A1 | QUINUCLIDINES-SUBSTITUTED-MULTI-CYCLIC-HETEROARYLS FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2002-12-19 | — | — | WO | disclosed |