SCHEMBL6844598

SCHEMBL6844598

COc1ccc([C](C)C)cc1OC

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 2/20 0.65
CYP2C19 P33261 2/20 0.65
TSHR P16473 2/20 0.65
CYP1A2 P05177 1/20 0.65
CYP3A4 P08684 1/20 0.65
CA12 O43570 1/20 0.63
CA1 P00915 1/20 0.63
CA2 P00918 1/20 0.63
CA4 P22748 1/20 0.63
CA6 P23280 1/20 0.63
CA7 P43166 1/20 0.63
TPMT P51580 1/20 0.63
CA9 Q16790 1/20 0.63
CA14 Q9ULX7 1/20 0.63
ALDH1A1 P00352 2/20 0.57
HPGD P15428 1/20 0.57
BACE1 P56817 1/20 0.57
HSD17B10 Q99714 1/20 0.57
MAPT P10636 2/20 0.56
POLB P06746 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16956653 0.84 ALDH1A1 (0.50) CYP2C9CYP2C19TSHRCYP1A2CYP3A4
SCHEMBL16956662 0.84 TSHR (0.70) TSHRALDH1A1HPGDMAPTSMN1; SMN2
SCHEMBL16950685 0.84 PDE4A (0.64) TSHRALDH1A1HPGDSMN1; SMN2PDE4A
SCHEMBL27917074 0.84 CA12 (0.67) CYP2C9CYP2C19TSHRCYP1A2CYP3A4
SCHEMBL16959609 0.82 KDM4E (0.55) CYP2C9CYP2C19TSHRCYP1A2CYP3A4
SCHEMBL16955021 0.82 CYP2C9 (0.47) CYP2C9CYP2C19TSHRCYP1A2CYP3A4
SCHEMBL20082281 0.82 CYP2C9 (0.61) CYP2C9CYP2C19TSHRCYP1A2CYP3A4
SCHEMBL8296526 0.82 CYP2C9 (0.61) CYP2C9CYP2C19TSHRCYP1A2CYP3A4
SCHEMBL9781811 0.82 TSHR (0.61) CYP2C9CYP2C19TSHRCYP1A2CYP3A4
SCHEMBL16950467 0.82 ALOX15 (0.56) CYP2C9CYP2C19TSHRCYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-3976695-A Halogen substituted α-(aminoalkyl)-3,4-dihydroxybenzyl alcohols SMITHKLINE CORPORATION (US) 1976-08-24 US claimed
CN-105668766-B Heavy-metal ion removal equipment and its minimizing technology in a kind of trade effluent 徐州工程学院 2018-02-02 CN disclosed
EP-2900645-A1 3-PHENYLISOXAZOLIN DERIVATIVES WITH HERBICIDAL ACTION Bayer CropScience AG (DE) 2015-08-05 EP disclosed
US-6770650-B2 CHEMOKINE RECEPTOR (CCR) ANTAGONISTS SUCH AS N-(1(S)-(4-(3,4-DICHLOROBENZYL)PIPERAZIN-1-YLMETHYL)-2-METHYLPROPYL)-4 -METHYLBENZAMIDE DIHYDROCHLORIDE SALT FOR TREATMENT OF ASTHMA SYNTEX (U.S.A.) LLC 2004-08-03 US disclosed
US-6323223-B1 CCR-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, METHODS FOR THEIR USE AND METHODS FOR PREPARING THESE COMPOUNDS. SYNTEX (U.S.A.) LLC 2001-11-27 US disclosed
CN-1040366-A Butenoic acid or acrylic acid derivative EISAI CO LTD (JP) 1990-03-14 CN disclosed
US-3976694-A BETA-ADRENERGIC STIMULANT, BRONCHODILATOR SMITHKLINE CORPORATION (US) 1976-08-24 US disclosed
US-3961076-A BRONCHODILATORS SMITHKLINE CORPORATION (US) 1976-06-01 US disclosed