Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | MYC | P01106 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.45 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1500169 | 0.84 | KDM4E (0.50) | KDM4EGLAAPEX1MYCNR4A1 | |
| SCHEMBL11380046 | 0.84 | HPGD (0.44) | KDM4EGLAAPEX1MYCNR4A1 | |
| SCHEMBL31125276 | 0.84 | KDM4E (0.55) | KDM4EGLAAPEX1MYCNR4A1 | |
| SCHEMBL3172005 | 0.84 | KDM4E (0.55) | KDM4EGLAAPEX1MYCNR4A1 | |
| SCHEMBL23243427 | 0.84 | KDM4E (0.55) | KDM4EGLAAPEX1MYCNR4A1 | |
| SCHEMBL1400054 | 0.82 | KDM4E (0.53) | KDM4EGLAAPEX1MYCNR4A1 | |
| SCHEMBL31529596 | 0.82 | KDM4E (0.58) | KDM4EGLAAPEX1MYCNR4A1 | |
| SCHEMBL12896001 | 0.82 | PTGDR2 (0.50) | KDM4EGLAMYCNR4A1HPGD | |
| SCHEMBL31053264 | 0.82 | KDM4E (0.53) | KDM4EGLAAPEX1MYCNR4A1 | |
| SCHEMBL25612072 | 0.82 | KDM4E (0.58) | KDM4EGLAAPEX1MYCNR4A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011044506-A2 | SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2011-04-14 | — | — | WO | disclosed |
| US-5395610-A | Agents for potentiating the effects of antitumor agents and combating multiple drug resistance | BURROUGHS-WELLCOME CO. (US) | 1995-03-07 | — | — | US | disclosed |